DOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS?

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dc.contributor.authorBasuguy, Erol
dc.contributor.authorOzkorkmaz, Ebru Gokalp
dc.date.accessioned2024-04-24T17:18:23Z
dc.date.available2024-04-24T17:18:23Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractGallic acid, acting as an antioxidant, anti -precipitant and cytoprotective agent, was used as a possible remedial natural component for treating experimentally induced esophageal burn. Wistar rats (n=24) were divided into three groups. Control group was given 1 mL 0.9% NaCl. Experimental esophageal burn was induced with 1 mL 40% NaOH application to the esophagus in groups 2 and 3. Gallic acid (R) (20 mg/kg) was administered to the treated group via oral gavage for 10 days. Removed tissues were fixed and paraffin blocks were prepared. Histopathological examination was performed after the sections had been stained with hematoxylin-eosin. Tumor necrosis factor alpha and caspase-3 antibodies were used on immunohistochemical analysis. In the esophageal burn group, necrosis, degeneration and numerous apoptotic cells, as well as intense inflammatory cell infiltration and fibrosis in the muscle layer were observed under light microscope. In the treated group, remodeling of epithelial cells with marked reduction in the connective tissue collagen content was observed, as well as marked reduction in the volume of collagen and abundance of inflammatory cells in blood vessels. Gallic acid treatment may help heal esophageal burns and prevent complications.en_US
dc.identifier.doi10.20471/acc.2023.62.03.5
dc.identifier.endpage446en_US
dc.identifier.issn0353-9466
dc.identifier.issn1333-9451
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85188276895
dc.identifier.scopusqualityQ3
dc.identifier.startpage437en_US
dc.identifier.urihttps://doi.org/10.20471/acc.2023.62.03.5
dc.identifier.urihttps://hdl.handle.net/11468/18759
dc.identifier.volume62en_US
dc.identifier.wosWOS:001187707500016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSestre Milosrdnice Univ Hospitalen_US
dc.relation.ispartofActa Clinica Croatica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEsophageal Burnen_US
dc.subjectGallic Aciden_US
dc.subjectTumor Necrosis Factor Alphaen_US
dc.subjectCaspase-3en_US
dc.subjectImmunohistochemistryen_US
dc.titleDOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS?en_US
dc.titleDOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS?
dc.typeArticleen_US

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