Effect of aloe vera on Mmp-1 and Timp-1 expression on diabetic wound healing

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dc.authorid0000-0001-5265-1487en_US
dc.authorid0000-0001-6453-0033en_US
dc.authorid0000-0001-5203-9650en_US
dc.authorid0000-0003-0734-2428en_US
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0002-1693-6378en_US
dc.contributor.authorSeyrek, Rohlat
dc.contributor.authorSöker, Sevda
dc.contributor.authorKaplan, Özge
dc.contributor.authorBaşaran, Süreyya Özdemir
dc.contributor.authorAşır, Fırat
dc.contributor.authorDeveci, Engin
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2023-11-02T06:06:55Z
dc.date.available2023-11-02T06:06:55Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractAim: The aim of this study is to investigate the healing aspect of aloe vera in diabetes mellitus, which inhibits wound healing. Methods: Diabetes model was created with streptozotocin. At the end of the 14-day experiment, blood glucose was measured from the tail vein of animals in all groups and blood was taken from the heart and sacrificed. Histopathology and immunohistochemical statistics and evaluation were performed. Results: Pycnosis and degeneration of epithelial cells were observed in diabetes groups. Leukocyte infiltration in the dermal papilla, degeneration of collagen fibers and an increase in the extracellular matrix were observed. It was observed that the epithelial layer in the aloe vera group was histologically close to the control group. It was observed that decreased inflammation in the dermal papilla and decreased in organized collagen fibers and vessel dilatation were observed. In the control group, MMP-1 and TIMP-1 expression were positive in the epidermis and dermis layers. In the diabetes group, weak expression of MMP-1 and TIMP-1 was observed in cells in the epidermis and dermis. The expression of MMP-1 and TIMP-1 in the surface epithelium in the aloe vera group was increased compared to the diabetes group. Conclusions: Aloe vera accelerated cell and extracellular matrix regeneration with its anti-oxidative activity.en_US
dc.identifier.citationSeyrek, R., Soker, S., Kaplan, Ö., Başaran, S. Ö., Aşır, F., Deveci, E. ve diğerleri. (2023). Effect of aloe vera on Mmp-1 and Timp-1 expression on diabetic wound healing. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, 6(2), 204-209.en_US
dc.identifier.doi10.36516/jocass.1268067
dc.identifier.endpage209en_US
dc.identifier.issn2667-498X
dc.identifier.issue2en_US
dc.identifier.startpage204en_US
dc.identifier.trdizinid1197794
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1197794
dc.identifier.urihttps://hdl.handle.net/11468/13023
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1197794
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorSeyrek, Rohlat
dc.institutionauthorKaplan, Özge
dc.institutionauthorBaşaran, Süreyya Özdemir
dc.institutionauthorAşır, Fırat
dc.institutionauthorDeveci, Engin
dc.institutionauthorSöker, Sevda
dc.language.isoenen_US
dc.publisherMerthan Tunayen_US
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetesen_US
dc.subjectWound healingen_US
dc.subjectMMPen_US
dc.subjectAloe veraen_US
dc.subjectTIMP-1en_US
dc.titleEffect of aloe vera on Mmp-1 and Timp-1 expression on diabetic wound healingen_US
dc.titleEffect of aloe vera on Mmp-1 and Timp-1 expression on diabetic wound healing
dc.typeArticleen_US

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