Evaluation of the Regeneration Effects of Systemically Applied Methylprednisolone and Vitamin B12 on Mental Nerve Crush Injury

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dc.contributor.authorKara, Cigdem
dc.contributor.authorLacin, Nihat
dc.contributor.authorAdak, Berat Metin
dc.contributor.authorKara, Alper
dc.contributor.authorTunik, Selcuk
dc.contributor.authorUysal, Ersin
dc.contributor.authorSoylu, Fahri Emrah
dc.date.accessioned2025-02-22T14:10:57Z
dc.date.available2025-02-22T14:10:57Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To evaluate the effects of methylprednisolone and vitamin B12 injection on the regeneration of the nerves after a mental nerve crush injury. MATERIAL and METHODS: A total of 40 albino Wistar rats have been randomly divided into four groups: Ynt: ÖNEMLİ: Turkish Neurosurgery_JTN 43470_proof reading group 1 (n=10): crush-like nerve damage was created by pinching the left mental nerve for 60 s with an aneurysm clip and intraperitoneally administered 1 ml of saline for 14 days; group 2 (n=10): the left mental nerve was pinched for 60 s with an aneurysm clip and intraperitoneally administered 2 mg/kg of methylprednisolone for 14 days; group 3, experimental group (n=10): the left mental nerve was pinched for 60 s with an aneurysm clip and intraperitoneally administered 2 mg/kg of vitamin B12 for 14 days; and group 4, experimental group (n=10): the left mental nerve was pinched for 60 s and intraperitoneally administered 2 mg/kg of methylprednisolone and 2 mg/kg of vitamin B12 for 14 days. All rats were sacrificed on the 28th postoperative day, and histopathological evaluation was performed. RESULTS: Nerve damage was higher in the control group than in other groups (p<0.05). When Neural Cell Adhesion Molecule (NCAM) expression levels were compared, no major differences were observed between the methylprednisolone and control groups (p>0.05). The B12 and B12+methylprednisolone groups reached significantly higher NCAM expression levels compared to the control and methylprednisolone groups. When the myelin basic protein (MBP) expression levels were compared (p<0.05), the MBP expression was significantly higher in all experimental groups than in the control group (p<0.05). CONCLUSION: Systemic vitamin B12 and methylprednisolone administration effectively supported remyelination in the crushed mental nerve by increasing Schwann cell proliferation and differentiation. © (2024), (Turkish Neurosurgical Society). All rights reserved.en_US
dc.description.sponsorshipEge Üniversitesi, (29.01.2020); Ege Üniversitesien_US
dc.identifier.doi10.5137/1019-5149.JTN.43470-23.3
dc.identifier.endpage772en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid39087280en_US
dc.identifier.scopus2-s2.0-85204309707en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage766en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.43470-23.3
dc.identifier.urihttps://hdl.handle.net/11468/29919
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250222
dc.subjectMental nerve damageen_US
dc.subjectMethylprednisoloneen_US
dc.subjectNerve crush injuryen_US
dc.subjectNerve regenerationen_US
dc.subjectRaten_US
dc.subjectVitamin B12en_US
dc.titleEvaluation of the Regeneration Effects of Systemically Applied Methylprednisolone and Vitamin B12 on Mental Nerve Crush Injuryen_US
dc.typeArticleen_US

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