A modular design of ruthenium(II) catalysts with chiral C2-symmetric phosphinite ligands for effective asymmetric transfer hydrogenation of aromatic ketones

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dc.contributor.authorAydemir, Murat
dc.contributor.authorMeric, Nermin
dc.contributor.authorBaysal, Akin
dc.contributor.authorGumgum, Bahattin
dc.contributor.authorTogrul, Mahmut
dc.contributor.authorTurgut, Yilmaz
dc.date.accessioned2024-04-24T16:18:27Z
dc.date.available2024-04-24T16:18:27Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractHydrogen-transfer reduction processes are attracting increasing interest from synthetic chemists in view of their operational simplicity. The new chiral C-2-symmetric ligands N,N'-bis-[(1S)-1-sec-butyl-2-O-(diphenylphosphinite)ethyl]ethanediamide, 1 and N,N'-bis-[(1S)-1-phenyl-2-O-(diphenylphosphinite)ethyl]ethanediamide, 2 and the corresponding ruthenium complexes 3 and 4 have been prepared and their structures have been elucidated by a combination of multi-nuclear NMR spectroscopy, IR spectroscopy, and elemental analysis. H-1-P-31 NMR, DEPT, H-1-C-13 HETCOR, or H-1-H-1 COSY correlation experiments were used to confirm the spectral assignments. The catalytic activity of complexes 3 and 4 in transfer hydrogenation of acetophenone derivatives by iso-PrOH has also been studied. Under optimized conditions, these chiral ruthenium complexes serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iso-PrOH and act as excellent catalysts, giving the corresponding chiral alcohols in 99% yield and up to 75% ee. This transfer hydrogenation is characterized by low reversibility under these conditions. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDicle University [DUBAP-07-01-22]en_US
dc.description.sponsorshipPartial support from Dicle University (Project number: DUBAP-07-01-22) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.tetasy.2010.04.002
dc.identifier.endpage710en_US
dc.identifier.issn0957-4166
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-77953135787
dc.identifier.scopusqualityN/A
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.1016/j.tetasy.2010.04.002
dc.identifier.urihttps://hdl.handle.net/11468/16105
dc.identifier.volume21en_US
dc.identifier.wosWOS:000279066200010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTetrahedron-Asymmetry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleA modular design of ruthenium(II) catalysts with chiral C2-symmetric phosphinite ligands for effective asymmetric transfer hydrogenation of aromatic ketonesen_US
dc.titleA modular design of ruthenium(II) catalysts with chiral C2-symmetric phosphinite ligands for effective asymmetric transfer hydrogenation of aromatic ketones
dc.typeArticleen_US

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