The Effect of Losartan on Deformities Occurring in Brain Tissue Craniectomy

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dc.contributor.authorAvinca, Oner
dc.contributor.authorKarakoc, Yenal
dc.contributor.authorTas, Mahmut
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:38:19Z
dc.date.available2024-04-24T17:38:19Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Traumatic brain injury is a major problem in the disruption of the blood-brain barrier integrity of nerve cells and glial cells. We aimed to investigate the antioxidant effects of losartan, an AT1 receptor blocker, on cell apoptosis with changes in the blood-brain barrier after craniectomy in a rat model. STUDY DESIGN: Male Sprague Dawley rats were randomly divided into 3 groups consisting of 10 rats each. The groups were as follows: control group, trauma group, and trauma +losartan group. After traumatic brain injury, blood samples were taken from the animals and analyzed with various biochemical markers. TUNEL assays and glial fibrillary acidic protein (GFAP) expressions were evaluated immunohistochemically. RESULTS: With TUNEL staining, positive expression was observed in posttraumatic neurons and glial cells. GFAP reaction was positive in degenerative astrocyte processes in the trauma group. In the trauma +losartan group, positive expression in astrocytes with regular structure around the blood vessels was observed. CONCLUSION: Losartan may cause release of cytochrome c via the mitochondrial pathway; however, it also may decrease cellular apoptosis.en_US
dc.identifier.endpage168en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85126591828
dc.identifier.scopusqualityQ4
dc.identifier.startpage161en_US
dc.identifier.urihttps://hdl.handle.net/11468/21406
dc.identifier.volume42en_US
dc.identifier.wosWOS:000609026800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCraniectomyen_US
dc.subjectCraniotomyen_US
dc.subjectGlial Cellsen_US
dc.subjectGlial Fibrillary Acidic Proteinen_US
dc.subjectLosartanen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectTunel Assayen_US
dc.titleThe Effect of Losartan on Deformities Occurring in Brain Tissue Craniectomyen_US
dc.titleThe Effect of Losartan on Deformities Occurring in Brain Tissue Craniectomy
dc.typeArticleen_US

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