Sonographic assessment of fatty liver: intraobserver and interobserver variability

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dc.contributor.authorCengiz, Mustafa
dc.contributor.authorSenturk, Senem
dc.contributor.authorCetin, Bulent
dc.contributor.authorBayrak, Aylin Hasanefendioglu
dc.contributor.authorBilek, Senem Uysal
dc.date.accessioned2024-04-24T17:49:50Z
dc.date.available2024-04-24T17:49:50Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide and ultrasonography is widely used in the diagnosis and the follow-up we purposed to assess intraobserver and interobserver variability in the sonographic evaluation of the existence and steatosis grades of NAFLD. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and AST to ALT (AST/ALT) ratio were compared between the grades of hepatosteatosis. Hepatic ultrasonography (US) examinations consisted of 5-10 static images of 113 successive adult patients, whose records were in the picture archiving and communication system (PACS) of our hospital were retrospectively evaluated by two experienced radiologists. Hepatic images were graded into 4 groups; as normal, mild, moderate or severe hepatic steatosis. Evaluation of hepatic steatosis of the same set of images was repeated after one month under the same conditions. Interobserver and intraobserver agreement was assessed by using kappa (kappa) statistics. In each group, the percentage of individuals with high ALT and/or AST, or AST/ALT ratio over 1 was calculated. The intraobserver agreement was 51%, fair kappa (kappa=0.356) for observer 1; and 68%, moderate (kappa=0.591) for observer 2. The interobserver agreements in the initial and second readings were 39% and 40%, fair (kappa=0.208) and (kappa=0.225), respectively. Elevations of ALT and/or AST levels were similar between groups depending on the degree of hepatosteatosis among the patients. Visual assessment of NAFLD by ultrasonography has substantial interobserver variability, and reproducibility of results is limited. More objective imaging modalities are needed to evaluate the degree of hepatosteatosis.en_US
dc.identifier.endpage5460en_US
dc.identifier.issn1940-5901
dc.identifier.issue12en_US
dc.identifier.pmid25664055
dc.identifier.startpage5453en_US
dc.identifier.urihttps://hdl.handle.net/11468/23005
dc.identifier.volume7en_US
dc.identifier.wosWOS:000348303600098
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatosteatosisen_US
dc.subjectInterobserver-Intraobserver Variabilityen_US
dc.subjectNaflden_US
dc.subjectUltrasonographyen_US
dc.titleSonographic assessment of fatty liver: intraobserver and interobserver variabilityen_US
dc.titleSonographic assessment of fatty liver: intraobserver and interobserver variability
dc.typeArticleen_US

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