The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder

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dc.contributor.authorTurgut, Fatma Subaşı
dc.contributor.authorBulut, Mahmut
dc.contributor.authorHattapoğlu, Salih
dc.contributor.authorGüneş, Mehmet
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorEkici, Faysal
dc.contributor.authorÇetinçakmak, Mehmet Guli
dc.date.accessioned2024-04-24T17:56:06Z
dc.date.available2024-04-24T17:56:06Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimlerien_US
dc.description.abstractIntroduction: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls’ orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD). Methods: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65. We used the ELISA method to evaluate serum SOD and GPx levels. Levels of NAA/Cr and Glx/Cr in the orbitofrontal cortex and caudate nucleus were measured using the 1H-MRS method. Results: Our study did not detect statistically significant differences in the orbitofrontal cortex Glx/Cr and NAA/Cr levels between the OCD patients and the control group. OCD patients exhibited a decrease in NAA/Cr levels, consistent with impaired neuronal integration, and an increase in Glx/Cr levels, consistent with hyperactivation, in the caudate nucleus compared to the control group. We observed a negative correlation between NAA/Cr levels in the caudate nucleus and the levels of SOD and GPx. Conclusions: Our study is the first to assess CN and OFC together in OCD patients using 3 T MR, investigating the relationship between neurometabolite concentrations and oxidative stress parameters. The negative correlation we observed between NAA/Cr levels and SOD and GPx in the caudate nucleus suggests that increased oxidative stress in this brain region in OCD patients may contribute to impaired neuronal integration and functionality. © 2024 Elsevier B.V.en_US
dc.description.sponsorshipDicle Üniversitesi: 14-TF-6en_US
dc.description.sponsorshipWe sincerely thank the Dicle University Scientific Research Projects Coordination Unit (DUBAP) for supporting our project. (Project Number: 14-TF-6). The funders had no role in the study design, data collection and analysis, publication decision, or manuscript preparation.en_US
dc.identifier.citationTurgut, F. S., Bulut, M., Hattapoğlu, S., Güneş, M., Kaya, M. C., Ekici, F. ve diğerleri. (2024). The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder. Brain Research, 1833, 1-7.
dc.identifier.doi10.1016/j.brainres.2024.148852
dc.identifier.issn0006-8993
dc.identifier.pmid38494099
dc.identifier.scopus2-s2.0-85188528100
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2024.148852
dc.identifier.urihttps://hdl.handle.net/11468/23292
dc.identifier.volume1833en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuronal integrityen_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectOxidative stressen_US
dc.subjectSingle proton magnetic resonance spectroscopyen_US
dc.titleThe relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorderen_US
dc.titleThe relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder
dc.typeArticleen_US

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