Effect of nimodipine on histological alterations in basilar artery following the bilateral common carotid artery ligation (preliminary study).

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dc.contributor.authorÖzkan, Ümit
dc.contributor.authorAydın, Mehmet Dumlu
dc.contributor.authorKemaloğlu, Mustafa Serdar
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorAydın, İsmail Hakkı
dc.date.accessioned2024-04-24T17:56:40Z
dc.date.available2024-04-24T17:56:40Z
dc.date.issued2004
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractBACKGROUND: The blood supply to tissues is reduced as a result of arterial occlusions. Angiogenesis, collateral circulation and reverse flow mechanisms go into operation to restore a continued adequate supply of blood. Ca++ channels undertake the major part of this function. As a result of the increasing tension on the arterial walls, vascular autonomy is affected, and ischemia and even necrosis are observed. METHOD: Adult 100 male hybrid rabbits were used in this study. The bilateral carotid arteries were ligated at the carotid bifurcation. The rabbits were divided into 2 main groups: treatment and control, and then both groups were further divided into 5 subgroups consisting of 10 rabbits each. The rabbits were sacrificed between the first day and the end of 8 weeks for histopathological examination of the basilar artery in two groups. RESULTS: In control groups, after 24 hours of the occlusion partial swelling and minor endothelial damage were observed in histopathological sections of the basilar artery. Luminal flattening started to decrease, and expanding of the diameter continued. The increase in the diameters of the basilar artery was higher in animals treated by nimodipine, and that difference was statistically significant (P=0,000). CONCLUSION: This study revealed that the intimal and medial alterations arising from the increased blood flow rate in the basilar artery might be lessened and even partially prevented by the use of nimodipine.en_US
dc.identifier.citationÖzkan, Ü., Aydın, M. D., Kemaloğlu, M. S., Yılmaz, F. ve Aydın, İ. H. (2004). Effect of nimodipine on histological alterations in basilar artery following the bilateral common carotid artery ligation (preliminary study). Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové, 47(1), 7-12.
dc.identifier.doi10.14712/18059694.2018.58
dc.identifier.endpage12en_US
dc.identifier.issn1211-4286
dc.identifier.issue1en_US
dc.identifier.pmid15168874
dc.identifier.scopus2-s2.0-2942652960
dc.identifier.scopusqualityQ3
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.14712/18059694.2018.58
dc.identifier.urihttps://hdl.handle.net/11468/23620
dc.identifier.volume47en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofActa medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of nimodipine on histological alterations in basilar artery following the bilateral common carotid artery ligation (preliminary study).en_US
dc.titleEffect of nimodipine on histological alterations in basilar artery following the bilateral common carotid artery ligation (preliminary study).
dc.typeArticleen_US

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