The fabrication of a highly sensitive electrochemical sensor based on AuNPs@graphene nanocomposite: Application to the determination of antidepressant vortioxetine

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dc.contributor.authorAtes, Ali Kemal
dc.contributor.authorEr, Engin
dc.contributor.authorCelikkan, Huseyin
dc.contributor.authorErk, Nevin
dc.date.accessioned2024-04-24T16:15:31Z
dc.date.available2024-04-24T16:15:31Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis is the first report to development of a new generation and highly sensitive electrochemical sensing platform based on gold nanoparticles/graphene/(AuNPs@GRP) nanocomposite for the detection of vortioxetine (VOR). The electrochemical behavior of VOR has been investigated through adsorptive stripping differential pulse voltammetry (AdsDPV) on the proposed electrochemical sensor (AuNPs@GRP/GCE). The structural and morphological characterizations of fabricated AuNPs@GRP composite were performed by x-ray diffraction (XRD) and transmission electron microscopy (TEM) methods. A well-defined and irreversible oxidation peak at 972 mV was observed on the surface of AuNPs@GRP/GCE. The proposed electrochemical sensor exhibited outstanding electrocatalytic activity towards the electroxidation of VOR. Under the optimized conditions, the voltammetric response was linearly proportional to VOR concentration at two working range of 0.1-1.0 and 1.0-6.0 mu M with a low detection limit of 50.0 nM. The developed sensor was successfully carried out for reliable determination of VOR in pharmaceutical sample with satisfying recovery results. AuNPs@GRP/GCE could be utilized as a simple, inexpensive and reliable sensing platform for the routine analysis of VOR as an antidepressant drug in pharmaceutical samples.en_US
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [15B0237001, 15L0237007]en_US
dc.description.sponsorshipThis research has been supported by Ankara University Scientific Research Projects Coordination Unit (Project Numbers: 15B0237001; 15L0237007).en_US
dc.identifier.doi10.1016/j.microc.2019.04.082
dc.identifier.endpage312en_US
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85065580822
dc.identifier.scopusqualityQ1
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1016/j.microc.2019.04.082
dc.identifier.urihttps://hdl.handle.net/11468/15832
dc.identifier.volume148en_US
dc.identifier.wosWOS:000474492600039
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrapheneen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectElectrochemical Sensoren_US
dc.subjectAdsorptive Stripping Voltammetryen_US
dc.subjectVortioxetineen_US
dc.subjectDeterminationen_US
dc.titleThe fabrication of a highly sensitive electrochemical sensor based on AuNPs@graphene nanocomposite: Application to the determination of antidepressant vortioxetineen_US
dc.titleThe fabrication of a highly sensitive electrochemical sensor based on AuNPs@graphene nanocomposite: Application to the determination of antidepressant vortioxetine
dc.typeArticleen_US

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