Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

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dc.contributor.authorAktas, Ayfer
dc.contributor.authorTasdemir, M. Serhan
dc.contributor.authorTuncer, M. Cudi
dc.contributor.authorNergiz, Yusuf
dc.contributor.authorAkkus, Murat
dc.contributor.authorBagriyanik, Husnu Alper
dc.date.accessioned2024-04-24T17:24:10Z
dc.date.available2024-04-24T17:24:10Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200-250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue.en_US
dc.identifier.doi10.4067/S0717-95022011000100025
dc.identifier.endpage150en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-79957476249
dc.identifier.scopusqualityQ3
dc.identifier.startpage144en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022011000100025
dc.identifier.urihttps://hdl.handle.net/11468/19474
dc.identifier.volume29en_US
dc.identifier.wosWOS:000290913400025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKidneyen_US
dc.subjectWistar-Albino Raten_US
dc.subjectStatinsen_US
dc.subjectAtorvastatinen_US
dc.subjectUltrastructuralen_US
dc.titleAtorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Studyen_US
dc.titleAtorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
dc.typeArticleen_US

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