Ruthenium(II) complexes derived from C2-symmetric ferrocene-based chiral bis(phosphinite) ligands: Synthesis and catalytic activity towards the asymmetric reduction of acetophenones
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Chiral secondary alcohols are very important building blocks and valuable synthetic intermediates both in organic synthesis and in the pharmaceutical industry for producing biologically active complex molecules. A series of new chiral Ru-phosphinite complexes (1, 2, 3, 4, 5, 6, 7, 8) were prepared from chiral C-2-symmetric ferrocenyl phosphinites and corresponding chloro complex, [Ru((6)-p-cymene)(-Cl)Cl](2). The complexes were characterized using conventional spectroscopic methods. The binuclear complexes were tested as pre-catalysts and were found to be good pre-catalysts for the asymmetric transfer hydrogenation of substituted acetophenones in basic 2-propanol at 82 degrees C, providing the corresponding optically active alcohols with almost quantitative conversion and modest to high enantioselectivities (46-97%). Amongst the all complexes, complex 6 gave the highest ee of 97% in the reduction of 2-methoxyacetophenone to (S)-1-(2-methoxyphenyl)ethanol at 82 degrees C. Copyright (c) 2015 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
Ferrocenyl bis(Phosphinite), C-2 symmetry, Asymmetric transfer hydrogenation, Acetophenone, Ruthenium
Kaynak
Applied Organometallic Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
29
Sayı
11
Künye
Ak, B., Durap, F., Aydemir, M. ve Baysal, A. (2015). Ruthenium(II) complexes derived from C2-symmetric ferrocene-based chiral bis(phosphinite) ligands: Synthesis and catalytic activity towards the asymmetric reduction of acetophenones. Applied Organometallic Chemistry, 29(11), 764-770.
