Effect of omeprazole, clarithromycin and amoxicillin therapy on duodenal ulcer and Helicobacter pylori eradication

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dc.contributor.authorGoral V.
dc.contributor.authorTas M.
dc.contributor.authorGul K.
dc.contributor.authorCanoruc F.
dc.date.accessioned2024-04-24T17:58:54Z
dc.date.available2024-04-24T17:58:54Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractHelicobacter pylori (H. pylori) is the most important factor in the pathogenesis of duodenal ulcer (DU). Eradication of H. pylori does lower the recurrence rate of DU. The aim of this study was to evaluate the efficacy, tolerability and compliance of a triple therapy with omeprazole and amoxicillin plus clarithromycin. 24 patients (22 males, 2 females, age range 21-27) with duodenal ulcer were treated for 2 weeks with omeprazole 20 mgr b.i.d. 28 plus amoxicillin 1 g b.i.d. plus daintromycin 250 mg. b.i.d. H. pylori (+) duodenal ulcer cases which were treated for 2 weeks with omeprazole 20 mgr b.i.d. plus amoxicillin 1 gr b.i.d., using as control groups. Diagnosis was made by upper G.I. endoscopy and by obtaining multiple biopsies from antral mucosa. Standard H.E., Giemsa stains and rapid urease test were performed for the diagnosis of H. pylori infection. Patients were endoscoped before and at the end of therapy and 1 month after completion of therapy. Eradication was defined as all tests were negative at the final evaluation. In the third endoscopy H. pylori positivity was found as 8%. The eradication was therefore reached in 22 patients (92%). At the control group, the eradication rate was calculated as 79% (p<0.05). It is concluded that a 2 weeks trial of triple therapy with omeprazole, clarithromycin and amoxicillin is very effective and well tolerated for the eradication of H. pylori infection.en_US
dc.identifier.endpage73en_US
dc.identifier.issn1300-4948
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0030887501en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://hdl.handle.net/11468/24146
dc.identifier.volume8en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuodenal Ulceren_US
dc.subjectHelicobacter Pylori Eradicationen_US
dc.titleEffect of omeprazole, clarithromycin and amoxicillin therapy on duodenal ulcer and Helicobacter pylori eradicationen_US
dc.title.alternativeDUODENAL ULSER TEDAVISINDE OMEPRAZOL, AMOKSISILIN VE KARITROMISIN KOMBINASYONUNUN HELICOBACTER PYLORI ERADIKASYONUNA ETKISIen_US
dc.typeArticleen_US

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