Effect of omeprazole, clarithromycin and amoxicillin therapy on duodenal ulcer and Helicobacter pylori eradication
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Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Helicobacter pylori (H. pylori) is the most important factor in the pathogenesis of duodenal ulcer (DU). Eradication of H. pylori does lower the recurrence rate of DU. The aim of this study was to evaluate the efficacy, tolerability and compliance of a triple therapy with omeprazole and amoxicillin plus clarithromycin. 24 patients (22 males, 2 females, age range 21-27) with duodenal ulcer were treated for 2 weeks with omeprazole 20 mgr b.i.d. 28 plus amoxicillin 1 g b.i.d. plus daintromycin 250 mg. b.i.d. H. pylori (+) duodenal ulcer cases which were treated for 2 weeks with omeprazole 20 mgr b.i.d. plus amoxicillin 1 gr b.i.d., using as control groups. Diagnosis was made by upper G.I. endoscopy and by obtaining multiple biopsies from antral mucosa. Standard H.E., Giemsa stains and rapid urease test were performed for the diagnosis of H. pylori infection. Patients were endoscoped before and at the end of therapy and 1 month after completion of therapy. Eradication was defined as all tests were negative at the final evaluation. In the third endoscopy H. pylori positivity was found as 8%. The eradication was therefore reached in 22 patients (92%). At the control group, the eradication rate was calculated as 79% (p<0.05). It is concluded that a 2 weeks trial of triple therapy with omeprazole, clarithromycin and amoxicillin is very effective and well tolerated for the eradication of H. pylori infection.
Açıklama
Anahtar Kelimeler
Duodenal Ulcer, Helicobacter Pylori Eradication
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
8
Sayı
1
