Decreased Elabela level in the first 24 hours of ST Elevation Myocardial Infarction patients

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dc.contributor.authorCanpolat Erkan, Revsa Evin
dc.contributor.authorAdiyaman, Mehmet Sahin
dc.date.accessioned2025-02-22T14:10:55Z
dc.date.available2025-02-22T14:10:55Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: Cardiovascular diseases are among the leading causes of death worldwide. ST Elevation Myocardial Infarction (STEMI) is one of the most important causes of cardiovascular mortality and morbidity. It has been determined that Elabela (ELA), a member of the apelinergic system, increases myocardial contractility and coronary vasodilation, and decreases blood pressure. The aim of this study was to evaluate the relationship between circulating ELA levels and various clinical, biochemical, and angiographic parameters in STEMI patients undergoing primary percutaneous coronary intervention (PCI). Methods: Seventy-four patients hospitalized with the diagnosis of STEMI who underwent coronary angiography and primary PCI, and seventy-four patients with chest pain but no pathology detected in coronary angiography, were included in the study as the control group. Coronary lesion severity was measured using the SYNTAX score tool. Routine laboratory tests and ELA levels were measured. Results: Plasma levels of ELA were significantly lower in patients with STEMI (0.68±0.68 ng/mL) than in controls (1.34±0.88 ng/mL, p<0.001). Glucose, cholesterol, LDL, CRP, troponin I, and SYNTAX score levels were statistically higher in the STEMI group, while ELA and HDL levels were lower. There was a high level of negative correlation between ELA and troponin I, SYNTAX score, cholesterol, LDL, and CRP. Conclusion: In this study, it was determined that the level of ELA decreased in the first 24 hours of STEMI patients. In addition, a highly negative correlation was found between ELA and troponin I and SYNTAX scores. © 2024, Association of Clinical Biochemistry Specialists (Klinik Biyokimya Uzmanlari Dernegi). All rights reserved.en_US
dc.identifier.doi10.14744/IJMB.2024.28159
dc.identifier.endpage155en_US
dc.identifier.issn2587-2362
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85203690132en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage150en_US
dc.identifier.trdizinid1280062en_US
dc.identifier.urihttps://doi.org/10.14744/IJMB.2024.28159
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1280062
dc.identifier.urihttps://hdl.handle.net/11468/29892
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherAssociation of Clinical Biochemistry Specialists (Klinik Biyokimya Uzmanlari Dernegi)en_US
dc.relation.ispartofInternational Journal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_Scopus_20250222
dc.subjectCoronary heart diseaseen_US
dc.subjectElabela (ELA)en_US
dc.subjectmyocardial infarctionen_US
dc.subjectprimary Percutaneous Coronary Intervention (PCI)en_US
dc.subjectST Elevation Myocardial Infarction (STEMI)en_US
dc.titleDecreased Elabela level in the first 24 hours of ST Elevation Myocardial Infarction patientsen_US
dc.typeArticleen_US

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