Essential oil contents of Hypericum linarioides , H. helianthemoides, and H. lydium with their biological activities: Importance of Hypericum genus in the cosmeceutical and pharmaceutical industries

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dc.authorid0000-0002-0988-9462en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0001-8319-9307en_US
dc.authorid0000-0002-6202-1515en_US
dc.authorid0000-0002-4377-0481en_US
dc.authorid0000-0002-0868-2769en_US
dc.authorid0000-0002-0339-635Xen_US
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYener, İsmail
dc.contributor.authorErtaş, Abdülselam
dc.contributor.authorDincel, Demet
dc.contributor.authorFırat, Mehmet
dc.contributor.authorKocakaya, Şafak Özhan
dc.contributor.authorYigitkan, Serkan
dc.contributor.authorTürkmenoğlu, Fatma Pınar
dc.contributor.authorAydın, Fırat
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2024-03-26T13:15:25Z
dc.date.available2024-03-26T13:15:25Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the last ten years, especially for H. perforatum. The importance of Hypericum species in traditional medicine and modern medicine is increasing day by day. From this point of view, the chemical composition of H. linarioides, H. helianthemoides, and H. lydium essential oils was analyzed by GC-MS/FID. In addition, their antioxidant, cytotoxic and antimicrobial activities along with their enzyme inhibitory potentials (cholinesterase, urease, tyrosinase, elastase and, collagenase) were defined. Also, in vitro and in silico studies of the major components of the species have been carried out on the studied enzymes. H. linarioides and H. helianthemoides were found to be rich in monoterpene hydrocarbons (63.96% and 43.86%, respectively), and H. lydium in sesquiterpene hydrocarbons (48.41%). The major components were indicated as α-pinene for H. linarioides (50.39%) and for H. helianthemoides (36.84%), and β-selinene for H. lydium (10.12%). H. lydium essential oil exhibited very high cytotoxic activity on breast cancer (MCF-7) (selectivity indices SI: 12) and colon cancer (HT-29) (SI: 2) cell lines. In particular, the selectivity indice value in MCF-7 cell lines of H. lydium could have natural therapeutic potential for breast cancer. H. lydium possessed neuropharmacological potential due to its high anticholinesterase activity. Since H. linarioides indicated high anti-aging potential (tyrosinase, elastase, and collagenase enzyme inhibitory activities), it could be used in the cosmetic industry.en_US
dc.description.sponsorshipDicle University ECZACILIK. 20. 003en_US
dc.identifier.citationAkdeniz, M., Yener, İ., Ertaş, A., Dincel, D., Fırat, M., Kocakaya, Ş. Ö. ve diğerleri. (2023). Essential oil contents of Hypericum linarioides , H. helianthemoides, and H. lydium with their biological activities: Importance of Hypericum genus in the cosmeceutical and pharmaceutical industries. Pharmaceutical Chemistry Journal, 57(9), 1460-1468.en_US
dc.identifier.doi10.1007/s11094-023-03011-y
dc.identifier.endpage1468en_US
dc.identifier.issn0091-150X
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-85181246453
dc.identifier.scopusqualityQ4
dc.identifier.startpage1460en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11094-023-03011-y
dc.identifier.urihttps://hdl.handle.net/11468/13740
dc.identifier.volume57en_US
dc.identifier.wosWOS:001134199900002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYener, İsmail
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorKocakaya, Şafak Özhan
dc.institutionauthorYiğitkan, Serkan
dc.institutionauthorAydın, Fırat
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-agingen_US
dc.subjectAnticholinesteraseen_US
dc.subjectCytotoxicityen_US
dc.subjectEssential oilen_US
dc.subjectHypericumen_US
dc.subjectMolecular modelingen_US
dc.titleEssential oil contents of Hypericum linarioides , H. helianthemoides, and H. lydium with their biological activities: Importance of Hypericum genus in the cosmeceutical and pharmaceutical industriesen_US
dc.titleEssential oil contents of Hypericum linarioides , H. helianthemoides, and H. lydium with their biological activities: Importance of Hypericum genus in the cosmeceutical and pharmaceutical industries
dc.typeArticleen_US

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