The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome

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dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorErel, Özcan
dc.contributor.authorOral, Hilmi Baha
dc.contributor.authorKöroğlu, Nadiye
dc.contributor.authorErgin, Merve
dc.contributor.authorTola, Esra Nur
dc.date.accessioned2024-04-24T19:11:21Z
dc.date.available2024-04-24T19:11:21Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Oxidative stress has been proposed as a potentialtrigger in the etiopathogenesis of polycystic ovary syndromerelatedinfertility. Thiol/disulphide homeostasis, a recently identifiedoxidative stress marker, is one of the antioxidant mechanism inhumans with critical roles in folliculogenesis and ovulation.Aims: To investigate follicular fluid thiol/disulphide homeostasis inthe etiopathogenesis of polycystic ovary syndrome and to determine itsassociation with in vitro fertilization outcome. The study procedureswere approved by the local ethics committee.Study Design: Cross-sectional study.Methods: Follicular fluid from 22 women with polycystic ovarysyndrome and 20 ovulatory controls undergoing in vitro fertilizationtreatment was sampled. Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp<0.0001, respectively). Disulphide levels, disulphide/native thiol,and disulphide/total thiol ratios were increased in the polycysticovary syndrome group (p<0.0001). A positive correlation betweenthe fertilization rate and native thiol (p=0.01, r=0.53) and totalthiol (p=0.01, r=0.052) among polycystic ovary syndrome patientswas found. A positive predictive effect of native thiol level on thefertilization rate in the polycystic ovary syndrome group was alsofound (p=0.03, ?=0.45, 95% CI= 0.031-0.643).Conclusion: Deterioration of thiol/disulphide homeostasis, especiallyelevated disulphide levels, could be one of the etiopathogeneticmechanisms in polycystic ovary syndrome. Increased native thiollevels are related to the fertilization rate among polycystic ovarysyndrome patients and are positive predictors of the fertilizationrate among polycystic ovary syndrome patients. Improvement ofthiol/disulphide homeostasis could be important in the treatment ofpolycystic ovary syndrome to increase in vitro fertilization success.en_US
dc.identifier.doi10.4274/balkanmedj.2017.1140
dc.identifier.endpage310en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.startpage306en_US
dc.identifier.trdizinid289746
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.2017.1140
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/289746
dc.identifier.urihttps://hdl.handle.net/11468/27938
dc.identifier.volume35en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndromeen_US
dc.titleThe Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome
dc.typeArticleen_US

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