The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Oxidative stress has been proposed as a potentialtrigger in the etiopathogenesis of polycystic ovary syndromerelatedinfertility. Thiol/disulphide homeostasis, a recently identifiedoxidative stress marker, is one of the antioxidant mechanism inhumans with critical roles in folliculogenesis and ovulation.Aims: To investigate follicular fluid thiol/disulphide homeostasis inthe etiopathogenesis of polycystic ovary syndrome and to determine itsassociation with in vitro fertilization outcome. The study procedureswere approved by the local ethics committee.Study Design: Cross-sectional study.Methods: Follicular fluid from 22 women with polycystic ovarysyndrome and 20 ovulatory controls undergoing in vitro fertilizationtreatment was sampled. Thiol/disulphide homeostasis was analyzedvia a novel spectrophotometric method.Results: Follicular native thiol levels, as well as the native thiol/total thiol ratio, were lower in the polycystic ovary syndrome groupthan in the non-polycystic ovary syndrome group (p=0.041 andp<0.0001, respectively). Disulphide levels, disulphide/native thiol,and disulphide/total thiol ratios were increased in the polycysticovary syndrome group (p<0.0001). A positive correlation betweenthe fertilization rate and native thiol (p=0.01, r=0.53) and totalthiol (p=0.01, r=0.052) among polycystic ovary syndrome patientswas found. A positive predictive effect of native thiol level on thefertilization rate in the polycystic ovary syndrome group was alsofound (p=0.03, ?=0.45, 95% CI= 0.031-0.643).Conclusion: Deterioration of thiol/disulphide homeostasis, especiallyelevated disulphide levels, could be one of the etiopathogeneticmechanisms in polycystic ovary syndrome. Increased native thiollevels are related to the fertilization rate among polycystic ovarysyndrome patients and are positive predictors of the fertilizationrate among polycystic ovary syndrome patients. Improvement ofthiol/disulphide homeostasis could be important in the treatment ofpolycystic ovary syndrome to increase in vitro fertilization success.
Açıklama
Anahtar Kelimeler
Kaynak
Balkan Medical Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
35
Sayı
4
