Antioxidative effects of alpha-lipoic acid in spinal cord injury an experimental rat model

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dc.contributor.authorErcan S.
dc.contributor.authorAktaş A.
dc.contributor.authorKemaloglu M.S.
dc.date.accessioned2024-04-24T18:46:38Z
dc.date.available2024-04-24T18:46:38Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. METHODS: 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. RESULTS AND DISCUSSION: Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. CONCLUSION: Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation. © 2021, Edizioni Luigi Pozzi. All rights reserved.en_US
dc.identifier.endpage102en_US
dc.identifier.issn0003-469X
dc.identifier.issue1en_US
dc.identifier.pmid33746123
dc.identifier.scopus2-s2.0-85103229938
dc.identifier.scopusqualityQ3
dc.identifier.startpage98en_US
dc.identifier.urihttps://hdl.handle.net/11468/25269
dc.identifier.volume92en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani di Chirurgia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectMethyl-Prednisoloneen_US
dc.subjectOxygen Radicalsen_US
dc.subjectSpinal Cord İnjuryen_US
dc.titleAntioxidative effects of alpha-lipoic acid in spinal cord injury an experimental rat modelen_US
dc.titleAntioxidative effects of alpha-lipoic acid in spinal cord injury an experimental rat model
dc.typeArticleen_US

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