Seroprevalence of serum HBSAg positivity and hepatitis delta virus infection among blood donors in Southeastern Turkey

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dc.contributor.authorMese S.
dc.contributor.authorNergiz S.
dc.contributor.authorTekes S.
dc.contributor.authorGul K.
dc.date.accessioned2024-04-24T17:58:32Z
dc.date.available2024-04-24T17:58:32Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims. HBV and HDV infection is still a serious health problem in Southeastern Turkey. In this study, we aim to investigate the prevalence serum HBsAg along with HDV infection among volunteer blood donors. Materials and Methods. This single centre and prospective study was performed in 6200 consecutive volunteer blood donors admitted to the Central Blood Bank of Dicle University Hospital. All adult blood donors included males and females were screened for HBsAg positivity. The positive serum samples for HBsAg were assessed for total anti-delta antibodies using the micro-ELISA method. Serum samples of anti-delta antibody positive cases were then examined for the presence of serum HDV RNA by real time, reverse transcription PCR method. Results. Six thousand two hundred adult volunteer blood donors were enrolled to the study. Of all analyzed blood donors, 6004 (96.8%) were men and 196 (3.2%) were women. Serum HBsAg positivity was found in 3% (186/6200) of 6200 blood donors. The mean age and female/ male ratio of HBsAg positive cases (n=186) were 32.85±10.04 years and 12/174, respectively. Serum anti-delta antibodies were detected in 6.98% (13/186) of HBsAg positive cases. The mean age of anti-delta antibody positive cases (n=13) was 44.5±13.61 years and female/ male ratio was 1/12. Moreover, 2 cases, (15.39%, 2/13) that were positive for anti-delta antibody, had serum HDV RNA positivity. Conclusions. It would be appropriate for HBsAg positive volunteer blood donors to be assessed regarding concurrent HDV infection as well. The magnitude of the contribution and benefi t that this screening would provide to our region, which is endemic for HDV infection, is the early diagnosis and management of this devastating disease. The real viremia in these cases can be best shown by using sensitive real time PCR method for the presence of serum HDV RNA. © Società Editrice Universo (SEU).en_US
dc.identifier.doi10.7471/CT.2014.1683
dc.identifier.endpage98en_US
dc.identifier.issn0009-9074
dc.identifier.issue2en_US
dc.identifier.pmid24770811
dc.identifier.scopus2-s2.0-84925873227
dc.identifier.scopusqualityQ2
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.7471/CT.2014.1683
dc.identifier.urihttps://hdl.handle.net/11468/23978
dc.identifier.volume165en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofClinica Terapeutica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Delta Antibodyen_US
dc.subjectBlood Donorsen_US
dc.subjectHbsagen_US
dc.subjectHdv Rnaen_US
dc.subjectHepatitis D Virusen_US
dc.titleSeroprevalence of serum HBSAg positivity and hepatitis delta virus infection among blood donors in Southeastern Turkeyen_US
dc.titleSeroprevalence of serum HBSAg positivity and hepatitis delta virus infection among blood donors in Southeastern Turkey
dc.typeArticleen_US

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