The role of Iron on breast cancer stem-like cells

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dc.contributor.authorOzer, U.
dc.date.accessioned2024-04-24T17:17:57Z
dc.date.available2024-04-24T17:17:57Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractIron is a fundamental nutrient that enables the functions of vital enzymes involved in cell replication, metabolism and growth. Cancer cells contain higher systemic iron levels relative to normal cells. In breast cancer cells, human epidermal growth factor receptor 2 (HER2) is over-expressed more than 30% of normal and its poorly prognosis results in elevated the proportion of cancer stem cells (CSCs) which are the main drivers in cancer recurrence. Finding a relation between increases of iron levels, HER2 expression and CSC population may provide new tools for breast cancer therapy. In this study, therefore, iron dependency in HER2 overexpression and CSC survival is examined in breast cancer cell line, MCF7. It has shown that cells overexpressing HER2 require iron more than their vector counterparts and HER2-increased CSCs are vulnerable to iron chelation. Additionally, this sensitivity of CSCs to iron reduction is obviously indicated in various breast cancer cell lines; HCC1954, MDA-MB-435 and Hs578T. Finally, the concept is also shown in neoplastically transformed breast cancer cell line, HMLER. Altogether, this study demonstrates that iron depletion causes toxicity for CSCs.en_US
dc.identifier.doi10.14715/cmb/2016.62.4.5
dc.identifier.endpage30en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue4en_US
dc.identifier.pmid27188730
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2016.62.4.5
dc.identifier.urihttps://hdl.handle.net/11468/18467
dc.identifier.volume62en_US
dc.identifier.wosWOS:000376410100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIronen_US
dc.subjectCscen_US
dc.subjectIron Chelatoren_US
dc.subjectHer2en_US
dc.titleThe role of Iron on breast cancer stem-like cellsen_US
dc.titleThe role of Iron on breast cancer stem-like cells
dc.typeArticleen_US

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