Significance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates

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dc.contributor.authorTunc, S. Y.
dc.contributor.authorGoruk, N. Y.
dc.contributor.authorAgacayak, E.
dc.contributor.authorIcen, M. S.
dc.contributor.authorFindik, F. M.
dc.contributor.authorKusen, H.
dc.contributor.authorEvsen, M. S.
dc.date.accessioned2024-04-24T17:15:12Z
dc.date.available2024-04-24T17:15:12Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To investigate the levels of growth differentiation factor-15 (GDF-15) in primary ovarian insufficiency (POI) and to evaluate its correlation with hormonal, biochemical, and inflammatory indicators. Materials and Methods: This comparative, cross-sectional study was carried out in 60 cases consisting of 30 healthy controls (mean age: 29.2 +/- 5.0 years) and 30 patients with POI (mean age: 28.9 +/- 6.8 years). Two groups were compared in terms of serum levels of glucose, lipids, thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), GDF-15, and neutrophil-lymphocyte ratios (NLR). Correlation between GDF-15 and NLR with these variables was sought. Results: Serum levels of FSH (p < 0.001), LH (p < 0.001), NLR (p < 0.001) and TSH (p = 0.020) were increased significantly in POI group. In POI patients, a correlation was detected between levels of GDF-15 levels and PRL (p = 0.049). Conclusion: The authors suggest that NLR can serve as a promising marker for diagnosis and follow-up of POI, whereas GDF-15 seems not to have such a potential.en_US
dc.identifier.doi10.12891/ceog3478.2017
dc.identifier.endpage733en_US
dc.identifier.issn0390-6663
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85037135076
dc.identifier.scopusqualityQ4
dc.identifier.startpage730en_US
dc.identifier.urihttps://doi.org/10.12891/ceog3478.2017
dc.identifier.urihttps://hdl.handle.net/11468/18372
dc.identifier.volume44en_US
dc.identifier.wosWOS:000410874100018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary Ovarian Insufficiencyen_US
dc.subjectGrowth Differentiation Factor-15en_US
dc.subjectNeutrophil Lymphocyte Ratioen_US
dc.subjectInflammationen_US
dc.titleSignificance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlatesen_US
dc.titleSignificance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates
dc.typeArticleen_US

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