Oxidative metabolism may be associated with negative symptoms in schizophrenia

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dc.contributor.authorGunes, Mehmet
dc.contributor.authorAltindag, Abdurrahman
dc.contributor.authorBulut, Mahmut
dc.contributor.authorDemir, Suleyman
dc.contributor.authorIbiloglu, Aslihan Okan
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorAtli, Abdullah
dc.date.accessioned2024-04-24T17:07:54Z
dc.date.available2024-04-24T17:07:54Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated. Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p <.05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p =.01, p =.01, respectively), Positive and Negative Syndrome Scale-Negative scores (p =.002, p =.001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p =.03, p =.03, respectively), and Clinical Global Impression-Severity Scale scores (p =.008, p =.009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p =.032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.en_US
dc.identifier.doi10.1080/24750573.2017.1293243
dc.identifier.endpage61en_US
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85037658229
dc.identifier.scopusqualityQ4
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2017.1293243
dc.identifier.urihttps://hdl.handle.net/11468/17083
dc.identifier.volume27en_US
dc.identifier.wosWOS:000401318800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectNegative Symptomsen_US
dc.subjectAntipsychotic Usageen_US
dc.subjectOxidative Stressen_US
dc.titleOxidative metabolism may be associated with negative symptoms in schizophreniaen_US
dc.titleOxidative metabolism may be associated with negative symptoms in schizophrenia
dc.typeArticleen_US

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