Role of vitamin D, folic acid, ferritin, inflammation and oxidative stress in the pathogenesis of COVID-19

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dc.authorid0000-0002-0773-2752en_US
dc.authorid0000-0002-8593-224Xen_US
dc.authorid0000-0003-1836-6281en_US
dc.authorid0000-0002-3402-2625en_US
dc.contributor.authorUnsal, Velid
dc.contributor.authorSabancılar, İlhan
dc.contributor.authorÖzbek, Erdal
dc.contributor.authorMermutluoğlu, Çiğdem
dc.contributor.authorTemiz, Hakan
dc.date.accessioned2023-10-24T12:43:50Z
dc.date.available2023-10-24T12:43:50Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractThe COVID-19 pandemic is one of the most devastating and significant events of recent times. COVID-19 has so far become one of the worst infectious disease outbreaks of recent times, with more than 635 million cases and more than 6.6 million deaths. Viruses cause an explosion of inflammatory cytokines and reactive oxygen types. Oxidative stress is thought to have a key role in COVID-19. vitamin D, folic acid, calcium (Ca), magnesium (Mg) and ferritin levels are thought to be associated with COVID-19. This study aims to investigate the role of oxidative stress, inflammation, vitamin D and folic acid, ferritin, Ca and Mg in the pathogenesis of COVID-19. Materials and Methods: 45 patients diagnosed with COVID-19 and 45 healthy persons (control group) were included in the study. Vitamin D, ferritin, folic acid, CRP, Ca, Mg and Phosphorus were measured in an autoanalyzer, and SOD, GSH-Px and MDA were spectrophotometrically measured in the serum of the participants. TNF-α, IL-1β and IL6 levels were studied by the ELISA method. Results: The activity of SOD, GSH-px, antioxidant enzymes, Serum vitamin D, folic acid, Ca and Mg of the COVID-19 group was found to be significantly lower than the control group (p<0.05). Conclusion: Again, the levels of MDA, TNF-α, IL-1β, IL-6, CRP and ferritin in the Covid-19 group were found to be significantly higher than in the control group (p<0.05).Antioxidant enzyme activities were low and oxidative stress was high in patients with COVID-19. At the same time, the levels of serum ferritin, CRP, TNF-α, IL-1β and IL6 were high, and levels of Ca and Mg were low in patients with COVID-19.According to these results, we hypothesize think that the level of oxidative stress, inflammation, vitamin D, and serum ferritin, Ca, and Mg levels play a role in the pathogenesis of COVID-19. Future clinical trials should be conducted to further clarify the pathogenesis in patients with COVID-19.en_US
dc.identifier.citationUnsal, V., Sabancılar, İ., Özbek, E., Mermutluoğlu, Ç. ve Temiz, H. (2022). Role of vitamin D, folic acid, ferritin, inflammation and oxidative stress in the pathogenesis of COVID-19. Progress in Nutrition, 24(2), 1-14.en_US
dc.identifier.doi10.23751/pn.v24i4.12306
dc.identifier.endpage14en_US
dc.identifier.issn1129-8723
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85149231935
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/12306/11170
dc.identifier.urihttps://hdl.handle.net/11468/12918
dc.identifier.volume24en_US
dc.indekslendigikaynakScopus
dc.institutionauthorSabancılar, İlhan
dc.institutionauthorÖzbek, Erdal
dc.institutionauthorMermutluoğlu, Çiğdem
dc.institutionauthorTemiz, Hakan
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress in Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectFerritinen_US
dc.subjectFolic aciden_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectVitamin Den_US
dc.titleRole of vitamin D, folic acid, ferritin, inflammation and oxidative stress in the pathogenesis of COVID-19en_US
dc.titleRole of vitamin D, folic acid, ferritin, inflammation and oxidative stress in the pathogenesis of COVID-19
dc.typeArticleen_US

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