Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?

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dc.contributor.authorKarahan, Mine
dc.contributor.authorHazar, Leyla
dc.contributor.authorErdem, Seyfettin
dc.contributor.authorAva, Sedat
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorDemirtaş, Atılım Armaǧan
dc.contributor.authorKeklikçi, Uğur
dc.date.accessioned2024-04-24T17:56:33Z
dc.date.available2024-04-24T17:56:33Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD). Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually. Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively. Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.en_US
dc.identifier.citationKarahan, M., Hazar, L., Erdem, S., Ava, S., Dursun, M. E., Demirtaş, A. A. ve diğerleri. (2021). Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?. Therapeutic Advances in Ophthalmology, 13, 1-7.
dc.identifier.doi10.1177/25158414211010550
dc.identifier.issn2515-8414
dc.identifier.scopus2-s2.0-85124757174
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1177/25158414211010550
dc.identifier.urihttps://hdl.handle.net/11468/23571
dc.identifier.volume13en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofTherapeutic Advances in Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAge-related macular degenerationen_US
dc.subjectMonocyte-to-lymphocyte ratioen_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPlatelet-to-lymphocyte ratioen_US
dc.titleIs there a relationship between hematological inflammatory parameters and age-related macular degeneration?en_US
dc.titleIs there a relationship between hematological inflammatory parameters and age-related macular degeneration?
dc.typeArticleen_US

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