Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD). Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually. Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively. Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.
Açıklama
Anahtar Kelimeler
Age-related macular degeneration, Monocyte-to-lymphocyte ratio, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio
Kaynak
Therapeutic Advances in Ophthalmology
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
13
Sayı
Künye
Karahan, M., Hazar, L., Erdem, S., Ava, S., Dursun, M. E., Demirtaş, A. A. ve diğerleri. (2021). Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?. Therapeutic Advances in Ophthalmology, 13, 1-7.
