Association between Serum Follistatin-Like Protein 1 Levels and Disease Activity in Behçet's Disease

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dc.contributor.authorDemir, Mesut
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorSariyildiz, Mustafa Akif
dc.contributor.authorEkinci, Aysun
dc.contributor.authorAkar, Zeynel Abidin
dc.contributor.authorBatmaz, Oznur
dc.contributor.authorKarakoc, Mehmet
dc.date.accessioned2024-04-24T16:24:08Z
dc.date.available2024-04-24T16:24:08Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction This study sought to determine the serum levels of follistatin-like protein 1 (FSTL-1), a glycoprotein of mesenchymal origin shown to be involved in the pathogenesis of many inflammatory diseases, for example Behcet's disease (BD), and to investigate its association with disease activity.Material and Methods The study included 45 patients followed for newly diagnosed Behcet's disease who met the 1990 International Study Group criteria for BD and a control group of 36 healthy volunteers who were age- and gender-matched. Peripheral blood samples were collected from the patients and control groups. Serum FSTL-1 levels were measured using an enzyme-linked immunosorbent assay. The disease activity was assessed using the Behcet's Disease Current Activity Form (BDCAF).Results A comparison of serum FSTL-1 levels in the patient and control groups found significantly higher levels of FSTL-1 in the patient group. Serum FSTL-1 levels were significantly higher in female patients compared with male patients. Female patients exhibited significantly higher BDCAF scores compared with male patients (p=0.008). Erythrocyte sedimentation rate and serum FSTL-1 levels were positively correlated.Conclusion Serum FSTL-1 levels may play a role in the aetiopathogenesis of BD and can also be a useful biomarker for determining disease activity.en_US
dc.identifier.doi10.1055/a-2201-6125
dc.identifier.issn0341-051X
dc.identifier.issn1438-9940
dc.identifier.scopus2-s2.0-85180924822
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1055/a-2201-6125
dc.identifier.urihttps://hdl.handle.net/11468/16528
dc.identifier.wosWOS:001128411900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofAktuelle Rheumatologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFollistatin-Like Protein 1en_US
dc.subjectBehcet-Krankheiten_US
dc.subjectKrankheitsaktivitaten_US
dc.subjectSedimentationsrate Der Erythrozytenen_US
dc.subjectDisease Activityen_US
dc.subjectErythrocyte Sedimentation Rateen_US
dc.subjectFollistatin-Like Protein 1en_US
dc.subjectBehcet's Diseaseen_US
dc.titleAssociation between Serum Follistatin-Like Protein 1 Levels and Disease Activity in Behçet's Diseaseen_US
dc.titleAssociation between Serum Follistatin-Like Protein 1 Levels and Disease Activity in Behçet's Disease
dc.typeArticleen_US

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