Re-Evalluation of Cases with Gastroenteropancreatic Neuroendocrine Tumors between 2004 and 2012 according to 2010 Criteria

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dc.contributor.authorOzkara, Selvinaz
dc.contributor.authorAker, Fugen
dc.contributor.authorYesil, Atakan
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorCanbey, Ceren
dc.contributor.authorYitik, Ali
dc.contributor.authorGonen, Can
dc.date.accessioned2024-04-24T17:28:02Z
dc.date.available2024-04-24T17:28:02Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: We re-evaluated the clinical, histopathological and immunohistochemical features of neuroendocrine tumors (NETs) diagnosed in our pathology laboratory between 2004 and 2012 and re-classified them according to the WHO-2000 and WHO-2010 criteria. Methodology: The study included NET samples of 106 patients having gastroenteropancreatic and hepatobiliary tumors. The histopathological findings were re-assessed. The cases were re-appraised based on the WHO-2000 and WHO-2010 criteria. The association between survival and Ki-67 index was analysed. Results: The most frequent localization was the stomach, The average tumor size was 3.0 +/- 4.1 cm. Differentiation was poor in 17 cases (16.0%). Lymphovascular invasion was detected in 16.1% (n=17) and necrosis was identified in 15.1% (n=16). The average number of Ki-67 was 9.1 +/- 19.9. Ki-67 measurements were significantly higher in patients who died compared to those who survived (p <0.01). In ROC analysis, the cut-off point for Ki-67 was 5. Conclusions: Our study is a single-center study comprising patients from Turkey for a period of 8 years. We found that the most frequent localization is the stomach. This ratio is associated with common use of endoscopy in our center. The specimens were re-evaluated according to the WHO-2000 and WHO-2010 classification systems the data and terminology have been updated.en_US
dc.identifier.doi10.5754/hge.13337
dc.identifier.endpage1672en_US
dc.identifier.issn0172-6390
dc.identifier.issue127en_US
dc.identifier.pmid24627925
dc.identifier.startpage1665en_US
dc.identifier.urihttps://doi.org/10.5754/hge.13337
dc.identifier.urihttps://hdl.handle.net/11468/20303
dc.identifier.volume60en_US
dc.identifier.wosWOS:000330011400023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastroenteropancreatic Neuroendocrine Tumorsen_US
dc.subjectWho-2010 Classification Systemsen_US
dc.subjectKi-67 Measurementsen_US
dc.titleRe-Evalluation of Cases with Gastroenteropancreatic Neuroendocrine Tumors between 2004 and 2012 according to 2010 Criteriaen_US
dc.titleRe-Evalluation of Cases with Gastroenteropancreatic Neuroendocrine Tumors between 2004 and 2012 according to 2010 Criteria
dc.typeArticleen_US

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