EFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIA

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dc.contributor.authorEr, A.
dc.contributor.authorUney, K.
dc.contributor.authorAltan, F.
dc.contributor.authorCetin, G.
dc.contributor.authorYazar, E.
dc.contributor.authorElmas, M.
dc.date.accessioned2024-04-24T17:18:42Z
dc.date.available2024-04-24T17:18:42Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractEffects of different doses of dexamethasone plus flunixin meglumine on survival rate were investigated in lethal endotoxemia. A total of 60 Balb/C female mice were divided into 4 equal groups. Lethal endotoxemia (80-100%) was induced by lipopolysaccharide injection (Group 1, 1 mg, intraperinoneally). At 4 hours after the lipopolysaccharide injection; low-dose dexamethasone (0.6 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously), normal-dose dexamethasone (2 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) and high-dose dexamethasone (10 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) were injected to Group 2, 3 and 4, respectively. After the injections, survival was monitored at 7 days and 13.3%, 13.3%, 33.3% and 73.3% survival rates were observed in Groups 1, 2, 3 and 4, respectively. As results, high-dose dexamethasone plus flunixin meglumine may be the treatment of choice for endotoxaemia in animals.en_US
dc.identifier.doi10.2298/AVB0901047E
dc.identifier.endpage51en_US
dc.identifier.issn0567-8315
dc.identifier.issn1820-7448
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-64549148455
dc.identifier.scopusqualityQ3
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.2298/AVB0901047E
dc.identifier.urihttps://hdl.handle.net/11468/18877
dc.identifier.volume59en_US
dc.identifier.wosWOS:000264662100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofActa Veterinaria-Beograd
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLethal Endotoxaemiaen_US
dc.subjectDexamethasoneen_US
dc.subjectFlunixinen_US
dc.subjectSurvival Rateen_US
dc.titleEFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIAen_US
dc.titleEFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIA
dc.typeArticleen_US

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