The Role of monocyte to high-density lipoprotein cholesterol ratio in predicting the severity of proteinuria and renal dysfunction in primary nephrotic syndrome
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cureus Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) has emerged as a novel marker of endothelial injury, inflammation, and oxidative stress. This study aimed to investigate the effect of MHR on primary nephrotic syndrome (NS) and its relationship with the severity of proteinuria.
Methods: This study enrolled 161 patients newly diagnosed with primary NS and 100 healthy individuals. Demographic characteristics of the patients, primary NS diagnosis, basal laboratory parameters, the amount of 24-hour urinary protein excretion, and MHR were recorded. The groups were compared regarding these parameters.
Results: MHR was significantly higher in patients with primary NS compared with the healthy group (12.89 +/- 4.86 and 9.71 +/- 2.30, respectively; p < 0.001). There was no difference between the groups in terms of age and sex. The amount of protein in the 24-hour urine in patients with a diagnosis of primary NS was 6.91 +/- 3.73 g/day. The correlation analysis showed a positive correlation between MHR and the amount of proteinuria (r = 0.519, p < 0.001) and creatinine level (r = 0.167, p = 0.034). The multivariate regression analysis found that the severity of proteinuria was independently correlated to MHR (p < 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off level for MHR in NS was 10.08 (area under the curve of 0.704, sensitivity of 68%, and a specificity of 62%).
Conclusion: Our study is the first to compare the severity of proteinuria and renal functions with MHR in patients with primary NS. We believe that MHR can be used as a biomarker to determine inflammation, endothelial injury, and the level of oxidative stress, and may be useful to predict prognosis in patients with primary NS.
Açıklama
Anahtar Kelimeler
Renal function, Inflammation, Proteinuria, Monocytes to high density lipoprotein cholesterol ratio, Nephrotic syndrome
Kaynak
Cureus Journal of Medical Science
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
13
Sayı
12
Künye
Aydın, F.Y., Eynel, E., Oruç, İ., İnce, H., Yüksel, E. ve Aydın, E. (2021). The Role of monocyte to high-density lipoprotein cholesterol ratio in predicting the severity of proteinuria and renal dysfunction in primary nephrotic syndrome. Cureus Journal of Medical Science, 13(12), 1-8.
