Effect of Zoledronic Acid Application on Different Graft Materials in Calvarial Bone Defect Models. An Experimental Analysis

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dc.contributor.authorKoparal, Mahmut
dc.contributor.authorGulsun, Belgin
dc.contributor.authorDeveci, Engin
dc.contributor.authorAgacayak, K. Serkan
dc.contributor.authorHamidi, Arif
dc.date.accessioned2024-04-24T17:47:33Z
dc.date.available2024-04-24T17:47:33Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the effect of zoledronic acid on graft materials in bone calvarial defects. STUDY DESIGN: Eighty adult (12 weeks) Sprague-Dawley male rats weighing from 300-350 g were divided into groups: calvarial defect, calvarial defect + synthetic graft, and calvarial defect + xenograft. All groups received zoledronate intravenously for a week after surgery and were sacrificed at either 6 or 12 weeks after their operation. The rat calvariae were fixed in 10% neutral buffered formalin before decalcification in 10% ethylenediaminetetraacetic acid for 20 days. Calvarial bone samples were then dehydrated and processed for embedding in paraffin wax. Sections 5 ?m thick were stained with hematoxylin and eosin and examined by light microscopy. RESULTS: The effects of zoledronic acid, a third-generation nitrogen-containing bisphosphonate, on different graft materials in rats with critical-size calvarial defects were analyzed and compared. Significantly less graft resorption was identified in zoledronic acid-treated rats that had received a xenograft than in either the untreated rats or those with a synthetic graft. In the xenograft group primary ossification was visible at week 12, and the graft had entered the bone to a greater extent than in the other experimental groups or in the control group. Osseous structures were also observed more clearly in this group than in the others. CONCLUSION: Zoledronic acid histopathologic bone graft stimulates bone formation. Zoledronic acid may be considered among the therapeutic methods available to improve the bone formation process in calvarial bone formation.en_US
dc.identifier.endpage125en_US
dc.identifier.issn0884-6812
dc.identifier.issue2en_US
dc.identifier.pmid27386633
dc.identifier.startpage117en_US
dc.identifier.urihttps://hdl.handle.net/11468/22594
dc.identifier.volume38en_US
dc.identifier.wosWOS:000381062200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiresorptive Drugsen_US
dc.subjectBone Defecten_US
dc.subjectBone Dysplasiasen_US
dc.subjectBone Graftsen_US
dc.subjectBone Regenerationen_US
dc.subjectBone Remodelingen_US
dc.subjectBone Resorptionen_US
dc.subjectBone Resorption Inhibitorsen_US
dc.subjectBone Resorption Inhibitory Agentsen_US
dc.subjectDevelop Mental Bone Diseaseen_US
dc.subjectFracture Healingen_US
dc.subjectOsteoconductionen_US
dc.subjectZoledronateen_US
dc.subjectZoledronic Aciden_US
dc.titleEffect of Zoledronic Acid Application on Different Graft Materials in Calvarial Bone Defect Models. An Experimental Analysisen_US
dc.titleEffect of Zoledronic Acid Application on Different Graft Materials in Calvarial Bone Defect Models. An Experimental Analysis
dc.typeArticleen_US

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