Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders

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dc.contributor.authorSimsek, Seref
dc.contributor.authorGencoglan, Salih
dc.contributor.authorOzaner, Soner
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorKaya, Mehmet Cemal
dc.date.accessioned2024-04-24T17:27:39Z
dc.date.available2024-04-24T17:27:39Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to investigate oxidative stress and DNA damage among children with attention deficit hyperactivity disorder (ADHD) with or without disruptive behavioral disorders (DBD). Methods: A total of 49 treatment naive children (M/F: 40/9) who were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria were included. The patients with ADHD were divided into two groups, those with ADHD alone (n= 25) and ADHD plus DBD (n= 24). The control group consisted of 40 age-and sex-similar healthy children. The Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Life-time version (K-SADS-PL) was applied to all children. Children's teachers completed the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S). Serum glutathione peroxidase (GPx), coenzyme Q, 8-hydroxy-2-deoxyguanosine (8-OHdG) and superoxide dismutase (SOD) levels were measured by the ELISA method using commercial kits. Results: There were no significant differences in serum GPx, SOD, CoQ and 8-OHdG levels among the pure ADHD, ADHD plus DBD and the control groups (p>0.05). No statistically significant correlations were found between the severity of ADHD symptoms and GPx, SOD, CoQ and 8-OHdG levels. Conclusion: Our study suggests that oxidative stress may not play a key role in the pathogenesis of pure ADHD and ADHD plus DBD.en_US
dc.description.sponsorshipDicle University Scientific Research Coordination Body [12-TF-124]en_US
dc.description.sponsorshipWe would like to thank our patients and their parents for taking part in this study. This study received financial support from Dicle University Scientific Research Coordination Body with project number of 12-TF-124.en_US
dc.identifier.doi10.5455/bcp.20151003063820
dc.identifier.endpage125en_US
dc.identifier.issn1017-7833
dc.identifier.issue2en_US
dc.identifier.startpage119en_US
dc.identifier.trdizinid201003
dc.identifier.urihttps://doi.org/10.5455/bcp.20151003063820
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/201003
dc.identifier.urihttps://hdl.handle.net/11468/20113
dc.identifier.volume26en_US
dc.identifier.wosWOS:000383390400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherKure Iletisim Grubu A Sen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAttention Deficit Hyperactivity Disorderen_US
dc.subjectChilden_US
dc.subjectDisruptive Behavioral Disordersen_US
dc.subjectOxidative Stressen_US
dc.subjectDna Damageen_US
dc.titleAntioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disordersen_US
dc.titleAntioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders
dc.typeArticleen_US

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