Phytochemical composition and toxicity assessment of Ammi majus L.

Basit Öğe Kaydı
dc.authorid0000-0002-5315-6063en_US
dc.authorid0000-0002-9188-2330en_US
dc.authorid0000-0001-6548-7823en_US
dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-9734-674Xen_US
dc.contributor.authorEl-Guourrami, Otman
dc.contributor.authorSalhi, Najoua
dc.contributor.authorBenkhouili, Fatima Zahra
dc.contributor.authorZengin, Gökhan
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorAmeggouz, Mouna
dc.date.accessioned2023-10-13T08:22:13Z
dc.date.available2023-10-13T08:22:13Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractObjective: To assess the acute and subacute toxicity as well as the phytochemical composition of two extracts and three fractions of Ammi majus L. Methods: The aqueous extracts were prepared separately by maceration for 48 h and by infusion for 1 h, while the fractions were prepared by the Soxhlet extractor, successively employing cyclohexane, ethyl acetate, and ethanol. The acute toxicity study was carried out in accordance with the OECD N°423 guideline at a single dose (2000 mg/kg) in mice for 14 days. The subacute toxicity study was performed by a daily oral administration of 250 mg/kg for 10 days and 100 mg/kg doses for 28 days. Phytochemical screening was performed using staining and precipitation reactions, while the chemical characterization of some analytes was detected by HPLC-MS/MS analysis. Results: In the acute toxicity study, no signs of toxicity such as convulsion, salivation, diarrhea, sleep and coma were observed during 30 minutes and 14 days, so the lethal dose was higher than 2000 mg/kg for each extract and fraction. The subacute toxicity results showed that at a dose of 250 mg/kg, 61.10% of the animals died and the rest developed morbidity. On the other hand, at a dose of 100 mg/kg, all the animals were still alive after 28 days, with no morbidity and the biochemical parameters were normal with no abnormalities in the liver, kidneys and pancreas. Phytochemical screening indicated the presence of flavonoids, tannins, coumarins, and free quinones and the absence of alkaloids and anthocyanins. Conclusions: The extracts and fractions of Ammi majus L. are not toxic in the short and long term with a varied chemical composition. Toxicological tests on animals other than rodents and in the long term (more than 28 days) are needed to further confirm the safety of Ammi majus extracts.en_US
dc.identifier.citationEl-Guourrami, O., Salhi, N., Benkhouili, F. Z., Zengin, G. Yılmaz, M. A. ve Ameggouz, M. (2023). Phytochemical composition and toxicity assessment of Ammi majus L. Asian Pacific Journal of Tropical Biomedicine, 13(4), 165-175.en_US
dc.identifier.doi10.4103/2221-1691.374233
dc.identifier.endpage175en_US
dc.identifier.issn2221-1691
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85160531745
dc.identifier.scopusqualityQ2
dc.identifier.startpage165en_US
dc.identifier.urihttps://journals.lww.com/aptb/pages/results.aspx?txtKeywords=Phytochemical+composition+and+toxicity+assessment+of+Ammi+majus+L.
dc.identifier.urihttps://hdl.handle.net/11468/12805
dc.identifier.volume13en_US
dc.identifier.wosWOS:000986831000004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute toxicityen_US
dc.subjectAmmi majus L.en_US
dc.subjectFlavonoidsen_US
dc.subjectPhytochemical compositionen_US
dc.subjectSubacute toxicityen_US
dc.titlePhytochemical composition and toxicity assessment of Ammi majus L.en_US
dc.titlePhytochemical composition and toxicity assessment of Ammi majus L.
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Phytochemical composition and toxicity assessment of Ammi majus.pdf
Boyut:
1.05 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Temel Eczacılık Bilimleri Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu