Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia in a Patient with Heterozygous for the Methylenetetrahydrofolate Reductase C677T Mutation: Case Report

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dc.contributor.authorSakalar, Y. Bayezit
dc.contributor.authorKeklikci, Ugur
dc.contributor.authorUnlu, Kaan
dc.contributor.authorCaca, Ihsan
dc.contributor.authorAlakus, Mehmet Fuat
dc.date.accessioned2024-04-24T17:27:36Z
dc.date.available2024-04-24T17:27:36Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractA 19-year-old male patient presented with blurring of vision in his left eye. Central retinal vein occlusion was detected on ophthalmic examination. Clinical examination and laboratory analysis were performed for risk factors predisposing him to retinal vein occlusion. His plasma homocysteine concentration was 14.30 U/mL. No other abnormalities were found in other hematologic tests. C677T heterozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) gene was detected by real-time polymerase chain reaction. A heterozygous mutation was detected in the same gene in the patient's mother, father and one of his sisters, also a homozygous mutation was detected in the other sister. Retinal vein occlusion in young patients may be related to mild hyperhomocysteinemia and a C677T mutation in the MTHFR gene.en_US
dc.identifier.doi10.5336/medsci.2010-17770
dc.identifier.endpage1100en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84860208702
dc.identifier.scopusqualityQ4
dc.identifier.startpage1097en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2010-17770
dc.identifier.urihttps://hdl.handle.net/11468/20079
dc.identifier.volume32en_US
dc.identifier.wosWOS:000309698500028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperhomocysteinemiaen_US
dc.subject5,10-Methylenetetrahydrofolate Reductase (Fadh2)en_US
dc.subjectRetinal Vein Occlusionen_US
dc.titleCentral Retinal Vein Occlusion Associated with Hyperhomocysteinemia in a Patient with Heterozygous for the Methylenetetrahydrofolate Reductase C677T Mutation: Case Reporten_US
dc.titleCentral Retinal Vein Occlusion Associated with Hyperhomocysteinemia in a Patient with Heterozygous for the Methylenetetrahydrofolate Reductase C677T Mutation: Case Report
dc.typeArticleen_US

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