Effect of intraperitoneal thymoquinone on postoperative peritoneal adhesions

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dc.contributor.authorBozdaǧ, Zübeyir
dc.contributor.authorGümüş, Metehan
dc.contributor.authorArıkanoğlu, Zülfü
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorKaya, Savaș
dc.contributor.authorEvliyaoǧlu, Osman
dc.contributor.orcid0000-0001-9568-5767
dc.contributor.orcid0000-0002-5780-9068
dc.date.accessioned2024-04-24T17:56:14Z
dc.date.available2024-04-24T17:56:14Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model. Materials and Methods: Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken. Results: There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05). Conclusions: Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.en_US
dc.identifier.citationBozdaǧ, Z., Gümüş, M., Arıkanoğlu, Z., İbiloğlu, İ., Kaya, S. ve Evliyaoǧlu, O. (2015). Effect of intraperitoneal thymoquinone on postoperative peritoneal adhesions. Acta Chirurgica Belgica, 115(5), 364-368.
dc.identifier.doi10.1080/00015458.2015.11681129
dc.identifier.endpage368en_US
dc.identifier.issn0001-5458
dc.identifier.issue5en_US
dc.identifier.pmid26560003
dc.identifier.scopus2-s2.0-84957415485
dc.identifier.scopusqualityQ3
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2015.11681129
dc.identifier.urihttps://hdl.handle.net/11468/23396
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/00015458.2015.11681129
dc.identifier.volume115en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherARSMB-KVBMGen_US
dc.relation.ispartofActa Chirurgica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of intraperitoneal thymoquinone on postoperative peritoneal adhesionsen_US
dc.titleEffect of intraperitoneal thymoquinone on postoperative peritoneal adhesions
dc.typeArticleen_US

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