Lysine-based two-component organogelator: Naproxen carrier soft material

Basit Öğe Kaydı
dc.authorid0000-0002-3774-2652en_US
dc.authorid0000-0002-4274-2729en_US
dc.authorid0000-0002-8571-5552en_US
dc.contributor.authorÇolak, Mehmet
dc.contributor.authorKaya, Gülşen
dc.contributor.authorHayaloğlu, Ali Adnan
dc.contributor.authorDemirel, Nadir
dc.contributor.authorHoşgören, Halil
dc.date.accessioned2024-03-21T11:02:59Z
dc.date.available2024-03-21T11:02:59Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalıen_US
dc.description.abstractWe demonstrated that Nϵ -alkanoyl-L-lysine ethyl ester/N-alkanoyl-L-phenylalaninate gelling agents were constructed as a two-component gelling strategy and applied as drug carriers in friendly solvents commonly used. Our designs are expected to have an edge in contrast to the other lipid-based systems due to cheap raw materials, reducing the required amount of carrier, low molecular weight, ease of loading, simple dose adjustability, skin spreadability, and improved drug retention times. It could be loaded with Naproxen (Npx) with a high loading efficiency (up to 100 % as a percentage of gelator) without gel disruption. A complementary in vitro drug release study under specific pH was conducted and performed at different drug and gelator concentrations. These results reveal that the release of Npx from the supramolecular organogels was significantly retarded with increasing organogelator engagement from 0.46 % to 0.92 %, the initial release rate considerably reduced, from 18.75 % to 7.21 %, respectively; that is release rate shows a 2.6-fold decrease; this result showed that the gelator concentration could control drug release. whereas the increasing Npx concentration enhanced it. Altogether, this work produces valuable outcomes, which may be relevant to the pharmaceutical industry, suggesting that new platforms may deliver NSAID (non-steroidal anti-inflammotory drug) molecules.en_US
dc.identifier.citationÇolak, M., Kaya, G., Hayaloğlu, A. A., Demirel, N. ve Hoşgören, H. (2023). Lysine-based two-component organogelator: Naproxen carrier soft material. ChemistrySelect, 8(46), 1-14.en_US
dc.identifier.doi10.1002/slct.202302968en_US
dc.identifier.endpage14en_US
dc.identifier.issn2365-6549
dc.identifier.issue46en_US
dc.identifier.scopus2-s2.0-85179355176en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202302968
dc.identifier.urihttps://hdl.handle.net/11468/13670
dc.identifier.volume8en_US
dc.identifier.wosWOS:001120897100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇolak, Mehmet
dc.institutionauthorHoşgören, Halil
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistrySelecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectControlled drug releaseen_US
dc.subjectLow Molecular Weight Organogelators (LMWOGs)en_US
dc.subjectRheologyen_US
dc.subjectSmall Molecule Gelling Agent (SMGA)en_US
dc.subjectSupramolecular gelsen_US
dc.titleLysine-based two-component organogelator: Naproxen carrier soft materialen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Lysine-Based Two-Component Organogelator.pdf
Boyut:
3.3 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Kimya Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu