Grading of the ovarian serous cystadencarcinomas, and its correlation with BRCA1 and p53 immunoreactivity

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dc.contributor.authorGuenes, Nedim
dc.contributor.authorYilmaz, Fahri
dc.contributor.authorUzunlar, Ali Kemal
dc.date.accessioned2024-04-24T17:37:29Z
dc.date.available2024-04-24T17:37:29Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Ovarian cancer is a gynecological malignancy with the higest mortality. The surface epithelial tumors of the ovary are the most common cancer types. The purpose of this study was to grade the ovarian serous cystadenocarcinomas and to evaluate BRCA1 and p53 proteins immunohistochemically. Material and Methods: Fifty-eight cases diagnosed as serous cystadenocarcinomas of the ovary were selected for this study. The cases were graded according to two-tier grading system, FIGO and Shimizu-Silverberg grading system and the results were compared. The BRCA1 and p53 proteins were studied immunohistochemically. Results: The cases were distributed as follows: according to the two-tier grading system low grade 12 (21%) cases and high grade 46 (79%) cases; according to the FIGO grading system grade 19 (16%) cases, grade B 29 (50%) cases, and grade 11120 (34%) cases and according to the Shimizu-Silverberg grading system grade 111 (19%) cases, grade II 29 (50%) cases, and grade 11118 (31%) cases. Positive p53 staining was detected in 57% (33/58) and BRCA1 was detected in 67% (39/58) of the cases. The relationship between p53 and BRCA1 proteins and histopathologic grade was analyzed. High grade ovarian serous carcinomas had a higher rate of p53 expression (65%) compared to low grade (25%) tumors. BRCA1 immunstaining was detected in 92% (11/12) of low grade and 61% (28/46) of high grade tumors according to two-tier grading system. Conclusion: There is a good correlation between the two-tier grading system and the FIGO and the Shimizu-Silverberg grading systems. In addition, the application of the two-tier grading system for ovarian serous carcinomas is easy because this system is based on easily understood two criteria and includes two categories (low grade, high grade). In contrast to p53, high grade tumors had a lower rate of BRCA1 expression (61%) compared to low grade (92%) tumors. In high-grade carcinomas, no statistical correlation was present between the p53 and BRCA1 positivity (p= 0.666).en_US
dc.identifier.endpage343en_US
dc.identifier.issn1300-0292
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-34447527671
dc.identifier.scopusqualityQ4
dc.identifier.startpage335en_US
dc.identifier.urihttps://hdl.handle.net/11468/20943
dc.identifier.volume27en_US
dc.identifier.wosWOS:000254582600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvaryen_US
dc.subjectCystadenocarcinomaen_US
dc.subjectGenes, P53en_US
dc.subjectBrca1 Proteinen_US
dc.titleGrading of the ovarian serous cystadencarcinomas, and its correlation with BRCA1 and p53 immunoreactivityen_US
dc.titleGrading of the ovarian serous cystadencarcinomas, and its correlation with BRCA1 and p53 immunoreactivity
dc.typeArticleen_US

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