The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

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dc.contributor.authorGulcan, Hayrettin Ozan
dc.contributor.authorYigitkan, Serkan
dc.contributor.authorOrhan, Ilkay Erdogan
dc.date.accessioned2024-04-24T17:18:34Z
dc.date.available2024-04-24T17:18:34Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractHigh cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled. Currently, the treatment of hypercholesterolemia is mainly achieved through the employment of statins in the clinic, although there are alternative drugs (e.g., ezetimibe, cholestyramine). In fact, the original statins are natural products directly obtained from fungi-like molds and mushrooms and they are potent inhibitors of hydroxymethylglutaryl-CoA reductase, the key enzyme in the biosynthesis of cholesterol. This review focuses on the first identification of natural statins, their synthetic and semi-synthetic analogues, and the validation of hydroxymethylglutaryl-CoA reductase as a target in the treatment of hypercholesterolemia. Furthermore, other natural products that have been shown to possess the potential to inhibit hydroxymethylglutaryl-CoA reductase are also reviewed with respect to their chemical structures.en_US
dc.identifier.doi10.2174/1570180816666181112144353
dc.identifier.endpage1137en_US
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85073682001
dc.identifier.scopusqualityQ3
dc.identifier.startpage1130en_US
dc.identifier.urihttps://doi.org/10.2174/1570180816666181112144353
dc.identifier.urihttps://hdl.handle.net/11468/18831
dc.identifier.volume16en_US
dc.identifier.wosWOS:000486625000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofLetters in Drug Design & Discovery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHmg-Coa Reductaseen_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectNatural Productsen_US
dc.subjectStatinsen_US
dc.subjectCholesterolen_US
dc.titleThe Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitorsen_US
dc.titleThe Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors
dc.typeReview Articleen_US

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