Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by LC-MS/MS of Bingöl Honeybee Pollen

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dc.authorid0000-0003-0788-4999
dc.authorid0000-0003-3373-1400
dc.authorid0000-0002-4090-7227
dc.authorid0000-0001-5608-554X
dc.authorid0000-0001-5993-1668
dc.contributor.authorİzol, Ebubekir
dc.contributor.authorTurhan, Münire
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇağlayan, Cüneyt
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2025-03-13T07:05:51Z
dc.date.available2025-03-13T07:05:51Z
dc.date.issued2025
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü
dc.description.abstractHoneybee pollen is the most important food and protein source for bees. It is a highly nutritious natural product for humans due to its content. Pollen shows different phytochemical content and variable biological activity according to different geography and vegetation. Therefore, in this study, the comprehensive phytochemical content by LC-MS/MS, and its antioxidant properties by different assays, with enzyme inhibition potential; antidiabetic, anticholinergic, and antiglaucoma properties, were determined from a pollen sample from Bingö l province, one of the significant beekeeping centers in Tü rkiye. As a result of LC-MS/MS, 15 metabolites were determined, and the highest concentration of quinic acid (1.531 mg analyte/g extract) was found. Antioxidant results: total phenolic content 113.14 mg GAE/g, total flavonoid content 64.11 mg QE/g, Fe3+ reduction 0.43 mu g/mL, CUPRAC 0.511 mu g/mL, FRAP 0.976 mu g/mL, DPPH IC50: 1.06 mu g/mL, ABTS IC50: 0.933 mu g/mL, and DMPD IC50: 0.598 mu g/mL. In addition, pollen showed antiglaucoma, anticholinergic, and antidiabetic properties by inhibiting carbonic anhydrase isoenzyme II (hCA II), acetylcholinesterase (AChE), and alpha- amylase enzymes, respectively. In this study, it was determined that Bingö l pollen has a comprehensive phytochemical content and antioxidant properties and, for the first time, inhibits hCA II, AChE, and alpha-amylase enzymes.
dc.identifier.citationİzol, E., Turhan, M., Yılmaz, M. A., Çağlayan, C., & Gülçin, İ. (2025). Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by LC-MS/MS of Bingöl Honeybee Pollen. Food Science & Nutrition, 13(3), e4531. https://doi.org/10.1002/fsn3.4531
dc.identifier.doi10.1002/fsn3.4531
dc.identifier.endpage11
dc.identifier.issn2048-7177
dc.identifier.issue3
dc.identifier.pmid40041710
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/fsn3.4531
dc.identifier.urihttps://hdl.handle.net/11468/32212
dc.identifier.volume13
dc.identifier.wosWOS:001436939700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorMustafa Abdullah, Yılmaz
dc.institutionauthorid0000-0002-4090-7227
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticholinergic
dc.subjectAntidiabetic
dc.subjectAntiglaucoma
dc.subjectAntioxidant
dc.subjectBee pollen
dc.subjectPhytochemical Content
dc.titleDetermination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by LC-MS/MS of Bingöl Honeybee Pollen
dc.typeArticle

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