Effects of salmon calcitonin and calcitonin gene related peptide (CGRP) on gastric mucosal barrier in stress induced rats

Basit Öğe Kaydı
dc.contributor.authorKanay, Z.
dc.contributor.authorKurt, D.
dc.contributor.authorGuzel, C.
dc.contributor.authorDenli, O.
dc.contributor.authorKetani, M. A.
dc.contributor.authorNas, K.
dc.date.accessioned2024-04-24T17:33:44Z
dc.date.available2024-04-24T17:33:44Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this investigation was to examine and compare the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier components such as mucus and phospholipids in rats exposed to cold + restraint stress (CRS). Twenty-eight Wistar albino rats (150 - 200 g) used for this study were provided by the Animal Health and Research Center of Dicle University Diyarbakir/Turkey (DUSAM). The rats were withheld from feeds for 24 h; then, they were divided into four groups - each of which consisted of seven rats such as: control, stress, and CGRP + CRS and sCT + CRS groups. CGRP and sCT were administered 10 mu g/kg intravenously 30 min prior to stress induction. After scarification of the rats, stomachs were examined macroscopically for ulcerative lesions. The amounts of mucus and phospholipids, which are important components of the gastric mucosal barrier, were then measured according to Corne and Baur methods. It was found that cold + restraining stress caused gastric lesions to increase, and that the application of CGRP and sCT decreased the lesions (P = 0.002, P = 0.001 respectively). Moreover, at the same time, it was determined that the decrease in the amount of mucus and phospholipids, due to the stress, was prevented significantly by administration of CGRP and sCT; for mucus as P = 0.002 and P = 0.002 respectively, for phospholipids as P = 0.002 and P = 0.002, respectively. According to our findings, CGRP and sCT were found to be effective in preventing acute hemorrhagic gastric lesions caused by stress, and in maintaining gastric mucosal barrier parameters.en_US
dc.description.sponsorshipCommission of Research Projects of Dicle University [DUAPK-03-VF-22]en_US
dc.description.sponsorshipThis research was supported by The Commission of Research Projects of Dicle University ( DUAPK-03-VF-22). Statistical analysis of this article was performed by Ersin UYSAL - Diyarbakir Vocational School Computer Programming. This study was presented in the XXXIIth International Congress of Turkish Physiology Sciences Association ( 18-22 September 2006)en_US
dc.identifier.endpage1454en_US
dc.identifier.issn1684-5315
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-66749090628
dc.identifier.scopusqualityN/A
dc.identifier.startpage1449en_US
dc.identifier.urihttps://hdl.handle.net/11468/20819
dc.identifier.volume8en_US
dc.identifier.wosWOS:000266174000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcitonin Gene Related Peptideen_US
dc.subjectGastric Mucosal Barrieren_US
dc.subjectSalmon Calcitoninen_US
dc.titleEffects of salmon calcitonin and calcitonin gene related peptide (CGRP) on gastric mucosal barrier in stress induced ratsen_US
dc.titleEffects of salmon calcitonin and calcitonin gene related peptide (CGRP) on gastric mucosal barrier in stress induced rats
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu