Effects of hesperidin on the changes made in the retinal damage induced by traumatic head injury

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dc.contributor.authorBalsak, Selahattin
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:33:41Z
dc.date.available2024-04-24T17:33:41Z
dc.date.issued2021
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: To investigate the protective effect of hesperidin on retinal damage induced by traumatic head injury. STUDY DESIGN: Thirty rats were divided into 3 groups: control, trauma, and trauma+hesperidin. The control group received only saline for 7 days without injury. Craniotectomy was created under anesthesia in the trauma group and the rats were administered intragastrically with saline solution for 7 days. In the trauma+hesperidin group, after craniotomy, 30 mg/kg hesperidin was administered for 7 days. At the end of the experiments, blood samples were collected and retinal tissues were processed. RESULTS: After trauma injury, hesperidin treatment reduced MDA and MPO values and increased GSH content in the trauma+hesperidin group. Dilation, inflammation, degenerated ganglion and photoreceptor cells, and Bcl-2 and TNF-alpha expressions were decreased in the trauma+hesperidin group. Hesperidin administration improved histology of the retina mostly in the trauma+hesperidin group. CONCLUSION: It has been predicted that hesperidin is effective in the regulation of cytokine activity, the TNF reaction, and the reduction of cell apoptosis triggered afterwards. It has been thought that the apoptotic process, which progresses in the direction of cell degeneration, may have a slowing effect in the nuclear loss phase of hesperidin treatment.en_US
dc.identifier.citationBalsak, S. ve Deveci, E. (2021). Effects of hesperidin on the changes made in the retinal damage induced by traumatic head injury. Analytical and Quantitative Cytopathology and Histopathology, 43(5), 337-344.
dc.identifier.endpage344en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85129317240
dc.identifier.scopusqualityQ4
dc.identifier.startpage337en_US
dc.identifier.urihttps://hdl.handle.net/11468/20801
dc.identifier.volume43en_US
dc.identifier.wosWOS:000765849100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectHesperidinen_US
dc.subjectInflammationen_US
dc.subjectTraumatic head injuryen_US
dc.titleEffects of hesperidin on the changes made in the retinal damage induced by traumatic head injuryen_US
dc.titleEffects of hesperidin on the changes made in the retinal damage induced by traumatic head injury
dc.typeArticleen_US

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