Anti-aging potential and anti-tyrosinase activity of three Hypericum species with focus on phytochemical composition by LC-MS/MS

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dc.contributor.authorErsoy, Ezgi
dc.contributor.authorOzkan, Esra Eroglu
dc.contributor.authorBoga, Mehmet
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorMat, Afife
dc.date.accessioned2024-04-24T16:14:56Z
dc.date.available2024-04-24T16:14:56Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractHypericum species are one of the most commonly used medicinal plants all over the world and traditional uses of the Hypericum species are mainly characterized by external applications for the treatment of dermatological disorders. The purpose of this study was to investigate the chemical compounds with anti-aging and anti-tyrosinase activities of Hypericum perforatum L., H. calycinum L., and H. confertum Choisy from Turkey and to bring innovation for further studies on developing formulations with Hypericum species for topical applications. In this study, chemical compositions of methanol extracts prepared from flowering aerial parts of the following species collected from Uludag, H. calycinum, H. confertum, and H. perforatum were investigated by LC-MS/MS. Nine metabolites, p-coumaric acid, gallic acid, quinic acid, chlorogenic acid, malic acid, protocatechuic acid, rutin, quercitrin, and isoquercitrin were identified in all analyzed species. To investigate the anti-aging and skin-whitening properties, enzyme inhibition activity of the three species were tested against, collagenase, elastase, hyaluronidase, and tyrosinase enzymes. H. calycinum appeared the most active in all enzyme inhibition activity assays which is mainly due to its rich phenolic content. The methanol extract of H. calycinum showed the highest collagenase, elastase and hyaluronidase inhibitory activities with IC50 values of 51.24 +/- 1.33 mu g/mL, 55.77 +/- 1.32 mu g/mL and 22.17 +/- 0.02 mu g/mL, respectively. Additionally, H. calycinum emerged as the most potential tyrosinase inhibitor among these species with 54.30 +/- 0.49% at 200 mu g/mL concentration. The most abundant compounds determined in H. calycinum methanol extract are, chlorogenic acid (2595.15 +/- 0.179 mu g/g), quercitrin (1805.9 +/- 0.98 mu g/g), quinic acid (885.50 +/- 0.073 mu g/g) and isoquercitrin (346.16 +/- 0.046 mu g/g), respectively. Our study demonstrates that all three extracts, especially H. calycinum extract are potential agents to use in cosmeceuticals for anti-aging and skin-whitening purposes.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [58219]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Istanbul University, Project number is 58219.en_US
dc.identifier.doi10.1016/j.indcrop.2019.111735
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85071608090
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2019.111735
dc.identifier.urihttps://hdl.handle.net/11468/15535
dc.identifier.volume141en_US
dc.identifier.wosWOS:000496611800008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndustrial Crops and Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypericumen_US
dc.subjectAnti-Aging Potentialen_US
dc.subjectAnti-Tyrosinase Activityen_US
dc.subjectChemical Compositionen_US
dc.subjectLc-Ms/Msen_US
dc.titleAnti-aging potential and anti-tyrosinase activity of three Hypericum species with focus on phytochemical composition by LC-MS/MSen_US
dc.titleAnti-aging potential and anti-tyrosinase activity of three Hypericum species with focus on phytochemical composition by LC-MS/MS
dc.typeArticleen_US

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