A multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ıs,gın (Rheum telianum) as an edible plant

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dc.contributor.authorTel, Ahmet Zafer
dc.contributor.authorAslan, Kubra
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2025-02-22T14:09:02Z
dc.date.available2025-02-22T14:09:02Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study reveals in vitro antioxidant properties and the phytochemical content of a novel Rheum species (Rheum telianum), which grows in Southeastern Anatolia. To perform the analysis, dried leaves and seeds of the plants were ground and extracted with ethanol to obtain plant secondary metabolites and antioxidant activity. Then, dried extracts were subjected to in vitro DPPH scavenging and Cupric reducing (CUPRAC), Fe3+, and Ferric reducing antioxidant power (FRAP). In addition to the antioxidant capacity assays, quantitative phenolic, flavonoid, and secondary metabolite were determined through spectrophotometric and LC-MS/MS chromatographic methods. IC50 values showed that both leaves and the seeds of the R. telianum have high inhibitory properties over DPPH radicals with 20.79 and 5.67 mu g/mL, respectively. The samples' dominant secondary metabolites were evaluated through the LC-MS/MS analysis results. The inhibition effects of both leaves and the seeds of the R. telianum extracts on acetylcholinesterase and butyrylcholinesterase, alpha-glycosidase and human carbonic anhydrases II isoenzyme enzymes, which associated with some global diseases including Alzheimer's disease, type-2 diabetes mellitus and glaucoma were determined. In conclusion, the extracts' contents and functional relationship and the plants' possible usage in the food, medicine, and cosmetic industries was revealed.en_US
dc.description.sponsorshipTUBAen_US
dc.description.sponsorshipIcenter dotlhami Gulcin is a member of the Turkish Academy of Sciences (TUBA). He wants to express his heartfelt gratitude to the TUBA for their financial assistance.en_US
dc.identifier.doi10.1016/j.fochx.2024.102125
dc.identifier.issn2590-1575
dc.identifier.scopus2-s2.0-85214460782en_US
dc.identifier.urihttps://doi.org/10.1016/j.fochx.2024.102125
dc.identifier.urihttps://hdl.handle.net/11468/29763
dc.identifier.volume25en_US
dc.identifier.wosWOS:001397884400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Chemistry-Xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectRheum telianumen_US
dc.subjectAntioxidant activityen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectalpha-glycosidaseen_US
dc.subjectRhubarben_US
dc.subjectPhenolic compounden_US
dc.titleA multidimensional study for design of phytochemical profiling, antioxidant potential, and enzyme inhibition effects of ıs,gın (Rheum telianum) as an edible planten_US
dc.typeArticleen_US

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