Intracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature

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dc.contributor.authorEskazan, Ahmet Emre
dc.contributor.authorAr, Muhlis Cem
dc.contributor.authorBaslar, Zafer
dc.date.accessioned2024-04-24T17:11:36Z
dc.date.available2024-04-24T17:11:36Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBACKGROUND: Extramedullary hematopoiesis (EH) is a compensatory phenomenon that results in the production of blood cell precursors outside the marrow in patients with chronic hemolytic anemia and ineffective erythropoiesis. EH usually involves the liver, spleen, and lymph nodes. It can also be found at paravertebral, intrathoracic, or pelvic locations. Intracranial EH is a rare entity and often asymptomatic but can sometimes lead to symptomatic tumor-like masses. Treatment options are controversial and include hypertransfusion, surgical excision, radiotherapy, and hydroxyurea (HU). STUDY DESIGN AND METHODS: Successful treatment of an intracranial EH mass with HU and blood transfusions in a beta-thalassemia major patient was discussed along with a review of the published literature on intracranial EH in thalassemia. RESULTS: In our patient, the extramedullary hematopoietic mass in the interhemispheric fissure showed a marked improvement after 6 months of HU and hypertransfusion therapy. In the English literature, there are a few cases with intracranial EH and thalassemia, which were treated with different treatment modalities, with different outcomes. CONCLUSION: There is no standard treatment approach in patients with symptomatic EH. HU with hypertransfusion regimen is a reasonable first-choice modality in treating intracranial EH masses.en_US
dc.identifier.doi10.1111/j.1537-2995.2011.03499.x
dc.identifier.endpage1720en_US
dc.identifier.issn0041-1132
dc.identifier.issn1537-2995
dc.identifier.issue8en_US
dc.identifier.pmid22220514
dc.identifier.startpage1715en_US
dc.identifier.urihttps://doi.org/10.1111/j.1537-2995.2011.03499.x
dc.identifier.urihttps://hdl.handle.net/11468/17628
dc.identifier.volume52en_US
dc.identifier.wosWOS:000307392800013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofTransfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleIntracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literatureen_US
dc.titleIntracranial extramedullary hematopoiesis in patients with thalassemia: a case report and review of the literature
dc.typeReview Articleen_US

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