Changing Trends in the Etiology of Cirrhosis in Türkiye: A Multicenter Nationwide Study

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dc.contributor.authorUcbilek, Enver
dc.contributor.authorYildirim, Abdullah Emre
dc.contributor.authorEllik, Zeynep
dc.contributor.authorTuran, Ilker
dc.contributor.authorHaktaniyan, Busra
dc.contributor.authorOrucu, Berk
dc.contributor.authorDemir, Mehmet
dc.date.accessioned2025-02-22T14:08:37Z
dc.date.available2025-02-22T14:08:37Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in T & uuml;rkiye.Materials and Methods: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in T & uuml;rkiye between January 2000 and June 2021. Results: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had Child-Pugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunc-tion-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLD-related cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extra-hepatic malignancies. Conclusion: Viral hepatitis remains the main cause of cirrhosis in T & uuml;rkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasingen_US
dc.identifier.doi10.5152/tjg.2024.23572
dc.identifier.issn2148-5607
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85205994317en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2024.23572
dc.identifier.urihttps://hdl.handle.net/11468/29511
dc.identifier.volume35en_US
dc.identifier.wosWOS:001344200200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCirrhosisen_US
dc.subjectetiologyen_US
dc.subjectviral hepatitisen_US
dc.subjectmetabolic dysfunction-associated steatotic liver diseaseen_US
dc.subjecthepatocellular carcinomaen_US
dc.titleChanging Trends in the Etiology of Cirrhosis in Türkiye: A Multicenter Nationwide Studyen_US
dc.typeArticleen_US

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