Side specific differences of tumor budding on non-metastatic colon cancer

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dc.contributor.authorSogutcu, N.
dc.contributor.authorGumus, S.
dc.contributor.authorBalkan, A. Z. Abidin
dc.contributor.authorBilge, H.
dc.contributor.authorCakabay, B.
dc.date.accessioned2024-04-24T17:47:34Z
dc.date.available2024-04-24T17:47:34Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: Recent literature suggests that tumor budding (TB) may have a significant clinical impact on colorectal cancers. Our study aims to reveal the effect of TB on the long-term outcomes of patients and to reveal whether there is a difference in tumor location and TB in colonic cancer. PATIENTS AND METHODS: A cohort of 100 patients with non-metastatic colon cancer was included in the study. The clinicopathological information of the patients was reviewed. Patients' preparations were reevaluated to identify TB as: low, medium, and high and represent 0-4 buds, 5-9 buds, and 10 or more buds per 0.785 mm2, respectively. Long-term oncological outcomes of patients were analyzed. The recurrence, metastasis, and final status of the patients were deter-mined during the follow-up period. RESULTS: Low TN was associated with < 65 year (p = 0.048), absence of lymphatic metastasis (p = 0.003), and absence of perineural invasion (p = 0.023). High TB was associated with higher pT stage (p = 0.017) and tumor stage (p = 0.005). Additionally, right-sided tumors had a high TB score than left side (82.3% vs. 23.6%, p = 0.011). Patients with high TB had lower overall survival, but these were not statically significant. According to multiple regression analysis, mortality risk was associated with age (p = 0.046), pN status (p = 0.003) and TB (p = 0.040). CONCLUSIONS: High TB is associated with mortality in colon cancer and is more common in right colonic carcinoma.en_US
dc.identifier.endpage7655en_US
dc.identifier.issn1128-3602
dc.identifier.issue20en_US
dc.identifier.pmid36314336
dc.identifier.startpage7649en_US
dc.identifier.urihttps://hdl.handle.net/11468/22604
dc.identifier.volume26en_US
dc.identifier.wosWOS:000883538600011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon Canceren_US
dc.subjectCancer Localizationen_US
dc.subjectTumor Buddingen_US
dc.titleSide specific differences of tumor budding on non-metastatic colon canceren_US
dc.titleSide specific differences of tumor budding on non-metastatic colon cancer
dc.typeArticleen_US

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