Association of omentin Val109Asp polymorphism with coronary artery disease

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dc.contributor.authorKarabacak, Ahmet
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorBulur, Serkan
dc.contributor.authorAslantaş, Yusuf
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorKaya, Ertuğrul
dc.date.accessioned2024-04-24T19:07:25Z
dc.date.available2024-04-24T19:07:25Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causesof death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and isinversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigatethe relationship between omentin Val109Asp polymorphism and CAD.Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography wereincluded in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and com-pared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison ofclinical characteristics according to the genotypes.Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49).Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to bemore in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experimentshould done with larger population to clarify this issue.en_US
dc.identifier.endpage514en_US
dc.identifier.issn1302-8723
dc.identifier.issn1308-0032
dc.identifier.issue6en_US
dc.identifier.startpage511en_US
dc.identifier.trdizinid170688
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/170688
dc.identifier.urihttps://hdl.handle.net/11468/27315
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAssociation of omentin Val109Asp polymorphism with coronary artery diseaseen_US
dc.titleAssociation of omentin Val109Asp polymorphism with coronary artery disease
dc.typeArticleen_US

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