Association of omentin Val109Asp polymorphism with coronary artery disease
[ X ]
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causesof death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and isinversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigatethe relationship between omentin Val109Asp polymorphism and CAD.Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography wereincluded in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and com-pared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison ofclinical characteristics according to the genotypes.Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49).Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to bemore in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experimentshould done with larger population to clarify this issue.
Açıklama
Anahtar Kelimeler
Kaynak
Anadolu Kardiyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
6
