Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation

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dc.contributor.authorSoker, Sevda
dc.contributor.authorDeveci, Engin
dc.contributor.authorYaman, Ferhan
dc.contributor.authorAtilgan, Serhat
dc.contributor.authorIpek, Fikret
dc.contributor.authorUysal, Ibrahim
dc.date.accessioned2024-04-24T17:33:44Z
dc.date.available2024-04-24T17:33:44Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractSildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n=7) were fed on standard laboratory diet until surgery. The study group (n=7) were administered sildenafil orally with orogastric tube 10 mg.kg(-1) once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were observed to cause degenerative changes in odontoblast with sildenafil. In the pulp tissue long-term use sildenafil is thought to cause degeneration and new vessel formation.en_US
dc.identifier.endpage574en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84978380242
dc.identifier.scopusqualityQ3
dc.identifier.startpage570en_US
dc.identifier.urihttps://hdl.handle.net/11468/20821
dc.identifier.volume34en_US
dc.identifier.wosWOS:000379751100025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSildenafilen_US
dc.subjectDental Pulpen_US
dc.subjectMorphological Changesen_US
dc.subjectImmunohistochemical Studyen_US
dc.subjectUltrastructural Studyen_US
dc.titleEffects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluationen_US
dc.titleEffects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation
dc.typeArticleen_US

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