EXPRESSION AND BIOLOGICAL ACTIVITY OF GHRELIN, OBESTATIN, AND LEPTIN IN DEFERENT DUCTS OF THE BULL AND RAM

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dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorErdogan, Serkan
dc.contributor.authorTopaloglu, Ugur
dc.contributor.authorAkbalik, Mehmet Erdem
dc.contributor.authorBayram, Bayram
dc.contributor.authorKetani, Muzaffer Aydin
dc.contributor.authorSagsoz, Hakan
dc.date.accessioned2024-04-24T17:20:23Z
dc.date.available2024-04-24T17:20:23Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractIt is known that ghrelin, obestatin and leptin are involved in many biological processes such as appetite-energy regulation, growth hormone release and cell proliferation. In addition to these biological activities of in human and rodents, direct effects of these hormones on reproductive functions and regulation of smooth muscle contractions have gained importance in recent years. In mammals, gonadal functions are regulated by using a complex network of autocrine, paracrine and endocrine signals. The signals involved in the control of energy balance regulate reproductive functions by acting on different hypothalamic pituitary-gonadal axis. The underlying molecular mechanism of gonad is poorly understood and appears to be controlled on genetic, environmental, and hormonal factors. Ghrelin, obestatin and leptin, three recently discovered hormones, are especially co-expressed in endocrine cells. The purpose of this investigation was to examine the immunohistochemical expression and potential biological activity of bull and ram deferent ducts (DD) in relation to the tissue concentration of ghrelin, obestatin and leptin. Ghrelin, obestatin and leptin expression observed in the DD sections were restricted to the cytoplasm of the epithelial and muscle cells. Both ghrelin and leptin expressions were found in smooth muscle cells in muscular layer of DD and smooth muscle cells of blood vessels, and obestatin expression was found in the basal epithelial cells of the luminal epithelium. In conclusion, ghrelin, obestatin and leptin were expressed in varying concentrations in epithelial and muscle cells as well as blood vessels of the deferent ducts of both species. Given the multifunctional biological roles of these peptide hormones, we can suggest that these hormones function in the contraction and hypertrophy of smooth muscles, proliferation or apoptosis of epithelial and muscle cells in DD.en_US
dc.identifier.doi10.26873/SVR-464-2018
dc.identifier.endpage159en_US
dc.identifier.issn1580-4003
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85054859272
dc.identifier.scopusqualityQ4
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.26873/SVR-464-2018
dc.identifier.urihttps://hdl.handle.net/11468/19004
dc.identifier.volume55en_US
dc.identifier.wosWOS:000446888900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherUniv Ljubljana, Veterinary Facultyen_US
dc.relation.ispartofSlovenian Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeferent Ductsen_US
dc.subjectGhrelinen_US
dc.subjectLeptinen_US
dc.subjectObestatinen_US
dc.subjectRuminanten_US
dc.subjectPhysiological Functionen_US
dc.titleEXPRESSION AND BIOLOGICAL ACTIVITY OF GHRELIN, OBESTATIN, AND LEPTIN IN DEFERENT DUCTS OF THE BULL AND RAMen_US
dc.titleEXPRESSION AND BIOLOGICAL ACTIVITY OF GHRELIN, OBESTATIN, AND LEPTIN IN DEFERENT DUCTS OF THE BULL AND RAM
dc.typeArticleen_US

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