The first application of C2-symmetric ferrocenyl phosphinite ligands for rhodium-catalyzed asymmetric transfer hydrogenation of various ketones

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dc.contributor.authorAk, Bunyamin
dc.contributor.authorAydemir, Murat
dc.contributor.authorDurap, Feyyaz
dc.contributor.authorMeric, Nermin
dc.contributor.authorBaysal, Akin
dc.date.accessioned2024-04-24T16:14:52Z
dc.date.available2024-04-24T16:14:52Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractHomogeneous catalysis has been responsible for many major recent developments in synthetic organic chemistry. The combined use of organometallic and coordination chemistry has produced a number of new and powerful synthetic methods for important classes of compounds in general and for optically active substances in particular. For this aim, a new class of chiral modular C-2-symmetric ferrocenyl phosphinite ligands has been prepared in good yields by using the inexpensive 1,1'-ferrocenedicarboxyaldehyde and various ferrocene based-amino alcohols as starting materials, and applied in the rhodium(I)-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones to give corresponding secondary alcohols with excellent enantioselectivities and reactivities using isoPrOH as the hydrogen source (up to 99% conversion and 99% ee). The substituents on the backbone of the ligands are found to exhibit a remarkable effect on both the activity and % ee. The structures of these ligands and their complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental analysis. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTubitak [111T419]en_US
dc.description.sponsorshipFinancial support from Tubitak (Project number: 111T419) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.ica.2015.09.003
dc.identifier.endpage51en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-84942626748
dc.identifier.scopusqualityQ2
dc.identifier.startpage42en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2015.09.003
dc.identifier.urihttps://hdl.handle.net/11468/15462
dc.identifier.volume438en_US
dc.identifier.wosWOS:000363867500008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Catalysisen_US
dc.subjectC-2-Symmetric Ferrocenyl Phosphiniteen_US
dc.subjectAsymmetric Transfer Hydrogenationen_US
dc.subjectAromatic Ketonesen_US
dc.subjectRhodium(I)en_US
dc.titleThe first application of C2-symmetric ferrocenyl phosphinite ligands for rhodium-catalyzed asymmetric transfer hydrogenation of various ketonesen_US
dc.titleThe first application of C2-symmetric ferrocenyl phosphinite ligands for rhodium-catalyzed asymmetric transfer hydrogenation of various ketones
dc.typeArticleen_US

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